Ductal hyperplasia

Fig. 13.8 Triple staining of a usual ductal hyperplasia for K5 (red), K8/18 (green) and SMA (pink). Note that the proliferating cells are only glandular cells. Myoepithelial cells are seen only in the outer layer (pink) and do not participate in the proliferation process...

Murray TJ, Mafflni MV, Ucci AA, et al. Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure. Reprod Toxicol 2007 23(3) 383 90. 

FIGURE 19.17 This case of florid duct hyperplasia (A) demonstrates strongly positive reactivity to keratin 903 (34pE12) (B). In contrast to ductal hyperplasia, DCIS (C) is negative with keratin 903 (D). 

Cytokeratin antibody 34 3E12 and CK5/6 routinely intensely stain florid ductal hyperplasia of the breast, which may be useful in separating florid DEH in ducts or papillomas from ADH/DCIS. 

Raju U, Vettes D. Breast papillomas with atypical ductal hyperplasia A clinicopathologic study. Hum Pathol. 1996 27 1231-1238. 

Rabban JT, Koerner PC, Lerwill MP. Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast A potentially difficult distinction resolved by cytokeratin 5/6. Hum Pathol. 2006 37 787-793. 

Schmid, B. C., Rudas, M., et al. (2004). CXCR4 is expressed in ductal carcinoma in situ of the breast and in atypical ductal hyperplasia. Breast Cancer Res Treat 84(3) 247-50. 

Fibrosis Cysts (blue-domed) Apocrine metaplasia Microcalcifications Ductal hyperplasia +/- Atypia Sclerosing adenosis Small duct papillomas... 

Mehta, R.G. et al.. Induction of atypical ductal hyperplasia in mouse mammary gland organ culture, J. Natl Cancer Inst, 93, 1103, 2001. 

Burbank F (1997b) Stereotactic breast biopsy of atypical ductal hyperplasia and ductal carcinoma in situ lesions improved accuracy with a directional, vacuum-assisted biopsy instrument. Radiology 202 843-847... 

---