Drugs tumor inhibitors

Drug Treatment for Inhibition of Tumor Cell Migration 1. Drug or inhibitor to be tested. Here we use cisplatin cis-diammineplatinum(ll) dichloride), stored in aliquots of 100 mM in dimethyl sulfoxide (DMSO) at -20°C for up to 4 weeks. 2. DMSO or appropriate solvent for the agent under test. 

Locate all the tetrahedral stereogenic centers in discodermolide, a natural product isolated from the Caribbean marine sponge Discodermia dissoluta. Discodermolide is a potent tumor inhibitor, and shows promise as a drug for treating colon, ovarian, and breast cancers. 

Below I outline briefly some recent findings in my laboratory in a program directed at tumor inhibitors of plant origin. This program, which has already led to the isolation of the active principles of more than 80 tumor-inhibitory extracts, has been the subject of two recent reviews (22). For this discussion of the future of plant-derived drugs, the stories of vernolepin and jatrophone will exemplify one important approach. 

Folic acid deficiency Hyperthermia Phenylketonuria Rheumatic disease Virilizing tumors Drugs and chemicals Androgenic chemicals Angiotensin-converting enzyme inhibitors Captopril, enalapril Antibiotics... 

Calpain inhibition may represent an important mechanism for future drug development. Control of calpain activity may limit the invasive properties of cells and thereby provides a possible mechanism to limit the invasiveness of tumors or inhibits the development of chronic inflammation. For the moment, pharmacological inhibitors of calpains are still not capable of differentiating among different calpain isoforms in cellular systems or in vivo. The importance of calpains in diseases will continue to stimulate the development of new and better inhibitors. 

Waldmann H, Thutewohl M (2000) Ras-Farnesyltransferase-Inhibitors as Promising Anti-Tumor Drugs. 211 117-130 Wang G-X, see Chow H-F (2001) 217 1-50 Weil T, see Wiesler U-M (2001) 212 1-40... 

Yet different elaboration of the same molecule affords a compound (162) that acts as an inhibitor to the pituitary peptide hormone prolactin, the factor responsible for supporting lactation. As such the drug has found use in suppressing lactation and in the treatment of prolactin-dependent breast tumors. 

---