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Drug withdrawal from market consequences

Drug Withdrawals From the Market - Causes and Consequences... [Pg.579]

CH44 DRUG WITHDRAWALS FROM THE MARKET - CAUSES AND CONSEQUENCES... [Pg.580]

Toxicity is a major cause for the withdrawal of drugs from the market and it is a major concern for pharmaceutical researchers. Reactive metabolism is certainly a very hot topic within the whole approach to drug metabolism. The downstream consequences of not identifying reactive metabolites may be financially catastrophic. There is an increasing drive to have early prediction of the metabolic fate and interactions of candidate drug molecules. Factors such as metabolic stability, toxic metabolite production, and P450 inhibition and induction are all routinely monitored to prevent compounds with poor pharmacokinetic properties from progressing forward onto clinical trials. [Pg.176]

See other pages where Drug withdrawal from market consequences is mentioned: [Pg.20]    [Pg.256]    [Pg.92]    [Pg.114]    [Pg.470]    [Pg.1388]    [Pg.262]    [Pg.146]    [Pg.147]    [Pg.118]    [Pg.8]    [Pg.301]    [Pg.479]    [Pg.785]    [Pg.34]    [Pg.355]    [Pg.34]    [Pg.82]    [Pg.131]    [Pg.268]    [Pg.138]    [Pg.178]   
See also in sourсe #XX -- [ Pg.3 , Pg.581 ]



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