Drug solubilization emulsion

Challenges with Emulsion Formulations for Drug Solubilization and Delivery. 215... 

Drug solubilization and delivery using emulsions does not lead to undesirable changes in its chemical stability, efLcacy, or toxicity. 

A Representative List of Experimental Studies Exploring Emulsion System for Drug Solubilization... 

All-trans-retinoicacid (ATRA) Hwang et al. (2004) Emulsion formulation enhanced drug solubilization and stabilization maintained antitumor activity... 

CHALLENGES WITH EMULSION FORMULATIONS FOR DRUG SOLUBILIZATION AND DELIVERY... 

Constantinides, P.P, Tustian, A., and Kessler, D.R. (2004)Tocol emulsion for drug solubilization and parenteral delivery.Adv. Drug Deliv. Rev., 56 1243-1255. 

Pramod K. Gupta and John B. Cannon. 2000. Emulsion and Microemulsions for Drug Solubilization and Delivery, inV feter-lnsoluble Drug Formulatiqnedited by Rong Liu, First edition, Interpharm/CRC, pp. 169-212. 

Constantinides PP, Tustian A, Kessler DR. Tocol emulsions for drug solubilization and parenteral delivery. Adv Drug Delivery 2004 56(9) 1243-1255. 

Constantinides PP, Tustian A, and Kessler DR. Toco Emulsions for Drug Solubilization and Parenteral Delivery. Adv Drug Del Rev 2004 56 1243—1255. 

The authors also found that their rod-coil systems proved to be feasible to encapsulate fullerens into the cavities. Compared to usual solvents for 50 and C70, such as dichloromethane or toluene, the solubility was enhanced by up to 1000 times when the molecules were encapsulated into rod-coil micelles. The solubilization of up to 10 billion fullerenes into one micelle increased the aggregation number to 10 and the obtained diameters up to 30 fim [136]. Such micro containers could also be used for an encapsulation process of other substances and so one can think of applications, such as drug delivery, emulsions, etc. 

Van Bloois, L., Dekker, D. D., and Crommelin, D. J. A. (1987). Solubilization of lipophilic drugs by amphiphiles Improvement of the apparent solubility of almitrine bismesylate by liposomes, mixed micelles and O/W emulsions, Acta Pharmaceut. TechnoL,... 

A surfactant is a surface-active agent that is used to disperse a water-insoluble drug as a colloidal dispersion. Surfactants are used for wetting and to prevent crystal growth in a suspension. Surfactants are used quite extensively in parenteral suspensions for wetting powders and to provide acceptable syringability. They are also used in emulsions and for solubilizing steroids and fat-soluble vitamins. 

The anhydrous petrolatum base may be made more miscible with water through the use of an anhydrous liquid lanolin derivative. Drugs can be incorporated into such a base in aqueous solution if desired. Poly-oxyl 40 stearate and polyethylene glycol 300 are used in an anti-infective ointment to solubilize the active principle in the base so that the ointment can be sterilized by aseptic filtration. The cosmetic-type bases, such as the oil-in-water (o/w) emulsion bases popular in dermatology, should not be used in the eye, nor should liquid emulsions, owing to the ocular irritation produced by the soaps and surfactants used to form the emulsion. 

Continuous aqueous phase emulsion polymerization is one of the most widely used procedures to make nanoparticles for drug delivery purposes, especially those prepared from the alkylcyanoacrylate monomers. An oil-in-water emulsion system is employed where the monomer is emulsified in a continuous aqueous phase containing soluble initiator and surfactant [39, 40]. Under these conditions, the monomer is partly solubilized in micelles (5-10 nm), emulsified as large... 

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