High-speed chemistry libraries, drug-likeness

High-Speed Chemistry Libraries Assessment of Drug-Likeness 149... 

The issues chemists deal with during lead optimization are the same that contribute to general drug-likeness the need to reduce toxicity or to improve solubility, oral absorption, blood-brain barrier penetration and metabolic stability. Computational methods that can directly predict these properties of compounds would allow for the design of high-speed chemistry libraries which are instrumental in solving these specific needs. 

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