Nonsteroidal anti-inflammatory drugs hepatotoxicity

Primary hepatocyte cultures have been used as a tool to predict the hepatotoxicity of many compounds such as nonsteroidal anti-inflammatory drugs (Castell et ah, 1988), psychotropic drugs (Boelsterli et ah, 1987), immunosuppressant drugs (Boelsterli et ah, 1988), and salicylates (Tolman et ah, 1978). Rat primary hepatocyte cultures have also been shown to be a good model for examining the mechanisms of metallothionein-induced tolerance to cadmium toxicity (Liu et ah,... 

Rubenstein JH, Laine L (2004) Systematic review the hepatotoxicity of nonsteroidal anti-inflammatory drugs. Aliment Pharmacol Ther 20 373-380. 

Chitturi S, George J (2002) Hepatotoxicity of commonly used drugs nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs. Semin Liver Dis 22 169-183. 

Forrester S D, Troy G C 1999 Renal effects of nonsteroidal anti-inflammatory drugs. Compendium on Continuing Education for the Practicing Veterinarian 21 910-919 Fry S W, Seeff L B 1995 Hepatotoxicity of analgesics and anti-inflammatory agents. Gastroenterology Clinics of North America 24 875-905... 

Despite the rigorous process for drug approval and regulation, several important medications have been removed from the market because of serious ADEs over the past 30 years. Examples of serious but uncommon effects include acute flank syndrome associated with suprofen," the gastrointestinal effects associated with nonsteroidal anti-inflammatory drugs (NSAIDs) in the elderly," troglitazone and the risk of hepatotoxicity," and the adverse effects of cisapride... 

Aithal, G. P., Day, C. P. (2007 Aug). Nonsteroidal anti-inflammatory drug-induced hepatotoxicity. Clinics in Liver Disease, 11 S), 563-575. 

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