Drug Guru transformation

Figure 11.3 Example of Drug Guru input and output. The input structure is dopamine. The 10 output structures resulting from the 10 catechol transformations listed in Table 11.2 are shown...

Figure 11.4 Assessment of Drug Guru performance of the Remove -Cl transformation for reducing hERG affinity (dofetilide displacement assay) using a matched molecular pair analysis of 151 compound pairs.

Chander Mohan was born in 1975 at Dhariwal, Punjab, India. He received his B.Pharm. and M.Tech.(Pharm.) in bulk drugs from Guru Nanak Dev University and the National Institute of Pharmaceutical Education and Research (NIPER), Mohali. After that he worked as senior chemist at Dr. Reddy s Research Foundation, Hyderabad. He then joined Professor M. P. Mahajan s research group in 2002 for his doctoral studies. His research is focused on the synthesis and chemical transformation of C-5/C-6-substituted pyrimidinones. His research interests include synthesis of medicinally important molecules, transition metal-induced transformations in organic synthesis, reaction mechanism and total synthesis of natural products. 

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