Grapefruit juice, drug interactions

Kane GC, Lipsky JJ. Drug-grapefruit juice interactions. 2000 75(9) 933-942. Mikkaichi T, Suzuki T, Tanemoto M, Ito S, Abe T. The organic anion transporter (OATP) family. Drug Metab Pharmacokinet 2004 19(3) 171-179. 

Table 4 Labeling Examples of Drug-Grapefruit Juice Interactions... 

Information in the PI is typically based on the studies submitted by a drug s manufacturer. The FDA has also utilized spontaneous adverse event case reports as a tool in the evaluation of drug-grapefruit juice interaction labeling. Other sources of data that contribute to labeled information include studies or case reports from the medical literature. 

Kane, G.C. and Lipsky, J.J., Drug-grapefruit juice interactions, Mayo Clin. Proc., 75, 933-942, 2000. 

To identify case reports containing information on drug and grapefruit juice interaction, the Adverse Event Reporting System (AERS) (2) database... 

Drugs that are already labeled for grapefruit juice interaction can also be reviewed to evaluate labeling for similar products, such as those that have... 

Fuhr, U. (1998). Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance. DrugSaf., 18, 251-72. 

Table 8 Drugs Known to Interact with Grapefruit Juice... 

DG Bailey, JMO Arnold, JD Spence. Inhibitors in the diet grapefruit juice-drug interactions. In RH Levy, KE Thummel, WE Trager, PD Hansten, M Eichelbaum, eds. Metabolic Drug Interactions New York Lippincott Williams Wilkins, 2000, pp. 661-667. 

Drug/Food interactions Administration of food with A/eora/decreases the ADC and Cmax of cyclosporine. A high-fat meal consumed within 30 minutes of Neoral administration decreased the AUC by 13% and Cmax by 33%. The effects of a low-fat meal were similar. In addition, do not take cyclosporine simultaneously with grapefruit juice unless specifically instructed to do so trough cyclosporine concentrations may be increased. 

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