Drug/gene delivery systems

It is usually difficult to add functionalities (i.e., to insert other amphiphilic molecules into a bilayer membrane) to self-assemble a bilayer nanoparticle after its self-assembly in solvents because the assembled bilayer membrane is a thermodynamically stable. If one can controlled the self-assemble phenomena, more complexed nanostrucutres can be achieved, and it will open a new stage of drug/gene delivery system. Bui et al. prepared a bilayer membrane nanoparticle via two-step self-assemblies using a solubility of amphiphilic block copolymer (Fig. 2.1.8) [108], The nanoparticles were composed of a positively charged complex core (siRNA and polyethyleneimine [PEI]) and a capsid-like (bilayer) shell. The preparation processes were divided into two steps (1) an electrostatic... 

Polymers as Drugs, Conjugates and Gene Delivery Systems... 

In this chapter, we describe the synthetic strategy for bio-inorganic conjugates which can be used as drug or gene delivery systems and their efficient cellular uptake mechanism. 

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Lin, A.J., Slack, N.L., Ahmad, A., Koltover, I., George, C.X., Samuel, C.E. and Safinya, C.R. (2000) Structure-function studies of lipid-DNA nonviral gene delivery systems. J. Drug Target., 8, 13-27. 

Park TG, Jeong JH, Kim SW (2006) Current status of polymeric gene delivery systems. Adv Drug Deliv Rev 58 467 -86... 

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