Drug filter

Norris RLG, Ahokas JT, Ravenscroft PJ (1982) Determination of unbound fraction of disopyramide in plasma a comparison of equilibrium dialysis, ultrafiltration through dialysis membranes and ultrafree anticonvulsant drug filters. J Pharmacol Methods 7(1) 7—14... 

To demonstrate text to lead prototype, a PubMed query was constructed with keywords malaria in conjunction with drugs filtered by title category in the MegaMiner portal. The limit on abstracts to be returned as hits was set to 15. This... 

Prediction of various physicochemical properties such as solubihty, lipophhicity log P, pfQ, number of H-donor and acceptor atoms, number of rotatable bonds, polar surface area), drug-likeness, lead-likeness, and pharmacokinetic properties (ADMET profile). These properties can be applied as a filter in the prescreening step in virtual screening. 

In general, the first step in virtual screening is the filtering by the application of Lipinski s Rule of Five [20]. Lipinski s work was based on the results of profiling the calculated physical property data in a set of 2245 compounds chosen from the World Drug Index. Polymers, peptides, quaternary ammonium, and phosphates were removed from this data set. Statistical analysis of this data set showed that approximately 90% of the remaining compounds had ... 

Other filters used for prefiltering account for lead- [22, 23] or drug-likeness [24-26], an appropriate ADMET profile [27-30], or favorable properties concerning receptor binding [31, 32]. 

Most practical implementations of drug-likeness use a computational model which takes as input the molecular structure, together with various properties, and predicts whether the molecule is drug-like or not. Some of these models may be very simple, such as a series of substructural filters. Only those molecules which pass all of these filters are output, Such filters can be used to eliminate molecules that contain inappropriate functionality. 

Cake Filters - These are filters that are used to remove large amounts of solids from a slurry solution. They would normally be seen in biotechnology in the primary clarification of fermentation batches and in a variety of solids removal steps seen in the production of drugs via organic synthesis. 

The Summary Drug Table Diuretics lists examples of die different types of diuretic drugp. Most diuretics act on die tubules of die kidney nephron (Pig. 46-1), the functional unit of the kidney. Each kidney contains about one million nephrons, which filter die bloodstream to remove waste products. During diis process,... 

Drug B is about 3% low relative to A, and both are about a further 1-2% low relative to the nominal content (if the amount of drug in a tablet is a small fraction of the total tablet weight, the slightest loss of drug to absorption on walls or in the air filters shows up in low assays). 

Ekins S, Berbaum J, Harrison RK. Generation and validation of rapid computational filters for Cyp2D6 and Cyp3A4. Drug Metab Dispos 2003 31 1077-80. 

Eye ointments are prepared in a semi-sohd base (e.g. Simple Eye Ointment BP, which consists of yellow soft paraffin, eight parts hqnid paraffin, one part wool fat, one part). The base is filtered when molten to remove particles and sterilized at 160°C for 2 hours. The drug is incorporated prior to sterilization if heat stable, or added aseptically to the sterile base. Finally, the prodnct is aseptically packed in clear sterile alumirtinm or plastic tnbes. Since the prodnct contains virtnally no water, the danger of bacteria proliferating in the ointment is neghgible. Therefore, there is no recommended maximum period during which they can be nsed. 

Filtered drug Absorbed (lipid-soluble) drug... 

The testing of impnrities in active pharmacentical ingredients has become an important initiative on the part of both federal and private organizations. Franolic and coworkers [113] describe the utilization of PLC (stationary phase — silica gel and mobile phase — dichloromethane-acetonitrile-acetone (4 1 1, v/v)) for the isolation and characterization of impurities in hydrochlorothiazide (diuretic drug). This drug is utilized individually or in combination with other dmgs for the treatment of hypertension. The unknown impurity band was scraped off the plate and extracted in acetonitrile. The solution was filtered and used for LC/MS and NMR analysis. The proposed procedure enabled the identification of a new, previonsly nnknown impurity. It was characterized as a 2 1 hydrochlorothiazide-formaldehyde adduct of the parent drug substance. 

Avdeef, A., Strafford, M., Block, E., Balogh, M. P., Chambliss, W., Khan, I. Drug absorption in vitro model filter-immobilized artifidal membranes 2. Studies of the permeability properties of lactones in Piper methysticum Forst. Eur.J. Pharm. Sci. 2001, 14, 271-280. 

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