Drug-Eluting stents polymers used

Dawkins KD, Grube E, Guagliumi G, et al. Clinical efficacy of polymer-based paclitaxel-eluting stents in the treatment of complex, long coronary artery lesions from a multicenter, randomized trial support for the use of drug-eluting stents in contemporary clinical practice, Circulation 2005 ... 

In summary, the field of drug-eluting stents, which are used for cardiovascular interventions, has come to rely deeply on polymer technology for the development of these implantable devices. Both synthetic and natural polymers are employed to enhance pharmaceutical deUvery and properties of the immunosuppressive drugs. 

Pharmaceutical Polymers Used for Drug-Eluting Stents... 

Resolute Integrity (Medtronic, Minneapolis, MN) is a 2012 PDA approved stent, that uses zotarolimus (160 g/cm ) that is 85% eluted in the first 2 months, blended with Biolinx polymer coated on a cobalt-chromium 91 micron strut. Despite its similarity with Endeavour, it was redesigned to have higher biocompatibility and controlled drug release. It was shown that Resolute had comparable results with everolimus eluting stents in the RESOLUTE All-comers trial [75-77], with other trials such as the TWENTE trial having comparable results [78]. Albeit Resolute is the only DES to be indicated specifically for diabetic patients, data from EXCELLENT and RESOLUTE-Korea show that the same could go for everolimus eluting stents [79]. 

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