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Drug Discovery in the Pharmaceutical Industry

Combinatorial chemistry, a new chapter of organic synthesis, is now developing rapidly. This new approach to synthesizing large designed or random chemical libraries through application of solid phase synthetic methods, promises to revolutionize the process of drug discovery in the pharmaceutical industry.24... [Pg.13]

The novel concept of High-Throughput Screening (HTS) assay, that has gained widespread popularity over the last two decades, is a valid approach to drug discovery and has become a standard method for drug discovery in the pharmaceutical industry [34],... [Pg.58]

Natural products represent an unparalleled source of molecular diversity for innovative drug discovery. In the pharmaceutical industry, there is an urgent need to identify novel lead structures for effective drug development in many therapeutic areas. It is likely that natural halogen compounds will continue to contribute leads to future research. [Pg.803]

Their computational results have been referred to as the Rule of Five, and it had a major impact on drug discovery in the pharmaceutical industry. The Rule of Five was implemented early on in the drug discovery process for all the drug discovery stages, particularly medicinal chemistry design, to avoid a designed compound with potential absorption and permeability failure. [Pg.126]

FIGURE 6.1 Drug-discovery process. The pharmaceutical industry usually divides the drug-discovery process into phases that are based on milestones (key indicators of progression). Text mining has specific application to some phases (see discussion in 6.3.3) but also has areas of broad utility that extend across the entirety of the process. The horizontal bars at the top of the figure indicate these broad utility areas. [Pg.154]

Owing to the personal interest and experience of the authors, the emphasis in this chapter is on using computers for drug discovery. But the use of computers in laboratory instruments and for analysis of experimental and clinical data is no less important. This chapter is written with young scientists in mind. We feel it is important that the new investigator have an appreciation of how the field evolved to its present circumstance, if for no other reason than to help steer toward a better future for those scientists using or planning to use computers in the pharmaceutical industry. [Pg.4]

The 1990s was a decade of fruition because the computer-based drug discovery work of the 1980s yielded an impressive number of new chemical entities reaching the pharmaceutical marketplace. We elaborate on this statement later in this section, but first we complete the story about supercomputers in the pharmaceutical industry. [Pg.27]

Schmid EF, Smith DA. Is declining innovation in the pharmaceutical industry a myth Drug Discovery Today 2005 10 1031-9. [Pg.50]


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