Drug discovery biological models

Daniele N, Halse R, Grinyo E, Yeaman SJ, Shepherd PR. Conditionally immortalized cell lines as model systems for high-throughput biology in drug discovery. Biochem Soc Trans 30 800-802 (2002). 

Fig. 3.1 Steps involved in drug discovery approach - a typical example. Joint efforts of classical genomics, proteomics, homology modelling, receptor- or structure-based screening approaches, and finally the structural biology efforts to determine the 3D structures of target reeeptor and receptor-ligand complex to get structural insight info their interactions...

Although the field of histone methyltransferase inhibitors is still in its infancy in terms of drug discovery, a lot of kno vledge in terms of their biological roles has been acquired. Test systems for in vitro and in vivo evaluation are available and model approaches have been presented already that led to inhibitors of these enzymes with promising cellular activity. Therefore, a dynamic development of the field can be expected vhich hopefully vill lead to clinical candidates in the upcoming years. 

Mazzoletti M, Texido G. (2013) In vivo target validation by inducible RNAi in human xenograft mouse models, methods in molecular biology. Target identification and validation in drug discovery. Eds. Jurgen Moll and Riccardo Colombo. 

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