Drug development stages

Drug development stage Dynamic range Extent of Specificity automation Efficiency Ruggedness... 

In the past decade, MS has become an indispensable tool for the pharmaceutical industry at each stage in drug discovery (see Table 4.1 [4]). Primarily, MS has been employed at the drug development stage. However, due to major advances in affinity-based MS technologies, it is readily becoming a common tool for hit identification in the drug discovery process (see Table 4.2 [4]). A common theme... 

For a further breakdown of the markets according to types of company and drug development stage, see Table 12.6. 

Clearly too little attention has been paid to the effect of food on drug absorption from sustained release formulations. It is still very common for adsorption studies in the drug development stage to be carried out in fasted subjects, even though, in clinical practice, fed conditions are far more usual... 

IV. Nonclinical Drug Development Stage (conducted concurrently with... 

Figure 42.3 provides a general overview over the main drug development stages, an approximate overall average duration and the likelihood of success for a drug as a function of its development stage. 

Note If developability assessment studies listed above have not been conducted, these studies should be included in the preclinical drug development stage.)... 

V. Clinical Drug Development Stage (Conducted Concurrently with Nonclinical Development)... 

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