Reviews, drug development

Schjpdt-Eriksen J, Clausen J. Optimization and simulation in drug development—review and analysis http //www.imm.dtu.dk/pubdb/views/edoc download.php/2834/ps/imm2834.ps... 

To improve systems of cind revise regulations for drug development, reviewing system and post-marketing surveillance in order to secure drug safety. 

A number of the stages of influenza A and B virus replication are targets for anti-influenza drug development (reviewed in [15,21,22]). A significant amount of research has focused on the functions of the viral surfeice glycoproteins. The surface of the influenza viruses consists of a host-derived lipoprotein envelope in which are embedded an integral ion channel protein and, depending on the virus... 

A recent review of option models in drug development, co-authored by a biostatistician from AstraZeneca in Molndal, Sweden [14], suggests that there has up to now been a lack of appreciation among pharmaceutical executives of the value that statistics could bring to the decision making process. This review quantifies the value of information that could terminate unsuccessful projects early and assesses the time-risk trade-off. It proves that projects split... 

Sheiner LB. Learning versus confirming in clinical drug development. Clin Pharmacol Ther 1997 Mar 61(3) 275-91. Review. 

Charnick SB, Kawai R, Nedelman JR, Lemaire M, Niederberger W, Sato H. Perspectives in pharmacokinetics. Physiologically based pharmacokinetic modeling as atoolfor drug development./P/jarmacokmefTEop/jarm 1995 Apr 23(2) 217-29. Review. 

Theil FP, Guentert TW, Haddad S, Poulin P. Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection. Toxicol Lett 2003 Feb 18 138(l-2) 29-49. Review. 

Lipinski, C.A., Lombardo, F., Dominey, B.W., Feeney, P.J. (1997) Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings. Advances in Drug Delivery Review, 46, 3-26. 

The New Drug Development Process Steps from Test Tube to New Drug Application Review, [Internet]. URL http //www.fda.gov/cder/handbook/ develop, htm, accessed 7-29-2000. 

Rekhi, G.S. and Jambhekar, S.S. (1995) Ethylcellulose - a polymer review. Drug Development and Industrial Pharmacy 21 61-77. 

Cutler NR and Sramek JJ (2001). Review of the next generation of Alzheimer s disease therapeutics Challenges for drug development. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 25, 27-57. 

Smith, J., Zhang, Y.L., and Niven, R., Toward development of non-viral gene therapeutics, Advanced Drug Delivery Reviews, 1997, 26, 135-150. 

Thermal methods can be extremely useful during the course of preformulation studies, since carefully planned work can be used to indicate the existence of possible drug-excipient interactions in a prototype formulation [2]. During the course of this aspect of drug development, thermal methods can be used to evaluate compound purity, polymorphism, solvation, degradation, drug-excipient compatibility, and a wide variety of other desirable characteristics. Several recent reviews have been written on such investigations [2-6]. 

Kassel, D. 2001. Combinatorial chemistry and mass spectrometry in the 21st century drug development laboratory. Chemical Reviews 101(2), 255-267. 

Pharmaceuticals, 18 682-721. See also Food and Drug Administration (FDA) Large-scale pharmaceutical synthesis Pharmaceutical products accelerated development/review for, 18 697... 

Horne R and Weinman J (1999) Patients beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. J Psychosom Res 47(6) 555-567 Kannisto V, Lauritsen J, Thatcher AR et al. (1994) Reductions in mortality at advanced age several decades of evidence from 27 countries. Population and development review 20(4) 793-810 Lazarou J, Pomeranz BH, Corey PN (1998) Incidence of adverse drug reactions in hospitalized patients a meta- analysis of prospective studies. JAMA 279(15) 1200-1205 LeSage J (1991) Polypharmacy in geriatric patients. Nurs Clin North Am 26(2) 273-290 Pitkala KH, Strandberg TE, Tilvis RS (2001) Is it possible to reduce polypharmacy in the elderly ... 

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