Drug dependence stimulants

Q Risk for Injury related to adverse drug effects (CNS stimulation, drug dependency, other [speafy])... 

Drugs that stimulate one receptor but block another are termed mixed agonist-antagonists. The effects of these drugs depend on previous exposure to opioids. In individuals who have not recently received opioids,... 

The property of drugs that allows these adaptive differences with conventional reinforcers is a basic one drugs enter the brain and directly activate or disinhibit DA neurons. In contrast, for their effects on DA neurons, conventional reinforcer drugs depend on the stimulation of a long chain of neurons triggered by stimulation of peripheral sensory receptors. 

TCAs DRUG DEPENDENCE THERAPIES-BUPROPION 1. t risk of seizures This risk is marked in elderly people, in patients with a history of seizures, addiction to opiates/cocaine/ stimulants, and in diabetics treated with oral hypoglycaemics or insulin 2. t plasma concentrations of amitriptyline, clomipramine, desipramine, doxepin and imipramine, with risk of toxic effects 1. Bupropion is associated with a dose-related risk of seizures. TCAs lower the seizure threshold. Additive effects when combined 2. Bupropion and its metabolite hydroxybupropion inhibit CYP2D6 1. Extreme caution. The dose of bupropion should not exceed 450 mg/day (or 150 mg/day in those with severe hepatic cirrhosis) 2. Initiate therapy of these drugs at the lowest effective dose... 

MDMA DRUG DEPENDENCE THERAPIES-BUSPIRONE Markedly t risk of serotonin syndrome Buspirone is a direct stimulant of 5-HT receptors (5-HT1A) Avoid concomitant use - For signs and symptoms of serotonin toxicity, see Qinical Features of Some Adverse Drug Interactions, Serotonin toxicity and serotonin syndrome... 

Definition A drug psychosis, drug dependence, non-dependent drug abuse and accidental poisoning caused by use of opiates, cocaine, stimulants, cannabis or hallucinogens. 

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