Drug delivery technology innovation

Despite tremendous innovations in the field of drug delivery technology, oral intake remains the preferred route of drug administration, for reasons of patient convenience and therapy compliance. Compounds intended for oral administration must have adequate biopharmaceutical properties in order to achieve therapeutic concentrations at the targeted site of action. 

CyDex, Innovative drug delivery technologies. www.captisol.com (accessed on 16 January 2003). 

Cevc, G. (2003). Transferosomes innovative transdermal drug carriers . In Rathbone, M.J., Hadgraft, J. and Roberts, M.S., eds., Modified release drug delivery technology. Marcel Dekker, New York, pp. 533-560. 

This section highlights advances in the use of polymer-based carriers in drug delivery. It shows how utilisation of polymers in a smart fashion could result in multiple responses at the desired point of action. The criteria and manufacturing requirements of a polymer-based nanocarrier are described in detail. Progress and innovations in drug-delivery technologies are also recounted. 

In other words, sol-gel entrapment technology provides innovative drug delivery solutions using sol gel based encapsulation systems in silica which enables new and stable combinations of APIs [active pharmaceutical ingredients] resulting in improved efficacy and usability . 

DirectHaler The DirectHaler (Direct-Haler A/S, Copenhagen, Denmark) nasal delivery device takes advantage of the nasal anatomy and an innovation in device technology in order to improve nasal drug delivery and patient compliance. Similar... 

Thirty years on from the explosion of commercially successful applications of targeted and controlled release pharmaceutical formulations, it is evident that there remains a need for further refinements and innovations in the field of drug delivery. Many of the larger corporations focus on the use of novel technology for extension of a product life cycle however, in many cases solubility and permeability issues limit the application of such technologies. Additional complications arise due to inter- and intrasubject variability, compliance, and chronobiological variation in disease incidence. 

Table 13 Some innovations in the Preparation of Drug Delivery Systems by Means of SCF Technology... 

Behzadi SS, Toegel S, and Viernstein H. Innovations in coating technology. Recent Patents on Drug Delivery and Formulation (2008) 2, 209-230. 

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