Drug delivery systems surface modification

Surface Modification Companies. Numerous companies engage in surface modification, but some have more of a focus on surface modification than others. SurModics is a U.S.-based drug delivery and surface modification company. Surface Modification Systems (SMS), in Galifornia, focuses on protective coatings. March Plasma Systems, also based in Galifornia, specializes in plasma treatments and plasma cleaning. 

The concept of de-PEGylation can be applied to the development of nanoparticle-based drug delivery systems. PEG is used for the modification of liposomes to increase their blood circulation time [38], However, it also prevents cellular uptake, resulting in a decrease in therapeutic efficiency thus, modifications of the liposome surface with PEG interfere with membrane fusion to the cell membrane and liposome decomposition [39]. One of the possible strategies to solve this problem is to cleave the PEG chains after the nanoparticle reaches the target site (Fig. 9). This system of de-PEGylation of liposomes is also useful in avoiding the immune... 

Surface modification is an important research line to obtain better materials for drug-delivery systems. Several techniques are used for the graft copolymerization of polysaccharides [30]. On grafting, the host biopolymer gains some properties of the... 

Surface modifications can act as binding sites for active agents in drug delivery systems or for toxins in purifying and treatment systems. These surface modifications may inter-diffuse upon heating to form the polymer matrix phase. The covalent linkage between reinforcement and matrix will result in a near-perfect stress transfer at the interface, resulting in exceptional mechanical properties of the composite. 

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