Drug delivery systems challenges

Intimately related to these factors is the design of the device, formulation, and the interface with the patient. Much of the discussion below will focus on the implications of excipients on formulation challenges for inhaled aerosol products. This chapter summarizes excipients for pulmonary formulations from several perspectives (i) excipient selection based on principles of delivery, (ii) physicochemical requirements for excipients, and (iii) specific challenges for formulations faced with aerosol drug delivery systems, including (a) biological aspects, (b) microbiological aspects, (c) analytical issues, and (d) future prospects. 

Bernkop-Schniirch, A., and M. Hornof. 2003. Intravaginal drug delivery systems Design, challenges, and solutions. Am J Drug Deliv 1 241. 

Yandamme, T.F. 2002. Microemulsions as ocular drug delivery systems Recent developments and future challenges. Prog Retin Eye Res 21 15. 

Challenges of drug delivery systems for intravenous administration 341... 

Tumor-targeted drug delivery systems can be classified based on three major approaches (i) passive targeting (ii) active targeting (Fig. 1) and (iii) external stimuli triggering. The advantages and challenges of each approach are discussed below. 

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