Drug challenges

This sensitization may extend to basal DA overflow as well as drug challenge-evoked DA overflow (Weiss et al. 1992a Parsons and Justice... 

Entirely new symptoms related to violence developed on the drug (challenge). 

Coyne AG, Scott DE, Abell C (2010) Drugging challenging targets using fragment-based approaches. Curr Opin Chem Biol 14 299-307... 

Likewise, polymorphisms in ion channels e.g., HERO, KvLQTl, Mink, and MiRPl) may affect the overall risk of cardiac dysrhythmias, which may be accentuated in the presence of a drug that can prolong the QT interval (e.g., macroUde antibiotics, antihistamines). These modifier polymorphisms may impact on the risk of disease phenotypes even in the absence of drug challenges in the presence of drug, the disease phenotype may be elicited. 

Spilker B (1996a) Orphan Drug Challenges for Pharmaceutical Companies. Drug News Perspect 9(7) 399. 

Renewed drug challenge causes the same syndrome... 

The authors thought that the child probably had a paradoxical reaction to cetirizine, although that was not confirmed by a subsequent drug challenge [8 ]. 

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