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Drug assay, electrochemical analysis

Radi [41] used an anodic voltammetric assay method for the analysis of omeprazole and lansoprazole on a carbon paste electrode. The electrochemical oxidations of the drugs have been studied at a carbon paste electrode by cyclic and differential-pulse voltammetry in Britton-Robin-son buffer solutions (0.04 M, pH 6-10). The drug produced a single oxidation step. By differential-pulse voltammetry, a linear response was obtained in Britton-Robinson buffer pH 6 in a concentration range from 2 x 10-7to 5 x 10 5 M for lansoprazole or omeprazole. The detection limits were 1 x 10 8 and 2.5 x 10 8 M for lansoprazole and omeprazole, respectively. The method was applied for the analysis of omeprazole in capsules. The results were comparable to those obtained by spectrophotometry. [Pg.210]

MS/MS) is the standard detector for bioanalytical assays and drug discovery screening, its use for routine assays of drug substances and products is still limited due to its high cost and lower precision. Nevertheless, LC/MS/MS methods are increasingly used for ultra trace analysis or screening of complex samples. Other detection options include conductivity detection for ionic species and electrochemical detection for neuroactive species in biochemical research. [Pg.199]

The minimum uncertainty for simple matrices is achieved with use of electrochemical sensors, especially for the assay of organic cations and organic and inorganic anions in food and clinical analysis. The selectivity and sensitivity of these sensors are adequate to detect numerous pharmaceutical products, without any prior separation. The ability of electrochemical sensors to determine continuously the activity of an ion in solution has made their use possible in in vitro and in vivo dissolution tests of drugs. [Pg.86]

Mesenteric effluents were collected at 1-min intervals up to 10 min during and following periarterial nerve stimulation. Coronary effluents were collected for 3 min at 15-sec intervals. In both cases samples were collected in plastic tubes containing 0.01 N perchloric acid and 0.025% EDTA, and stored at — 70°C until analysis. All samples were analyzed within 3 weeks. NE was determined by high-performance liquid chromatography coupled with electrochemical detection (Imamura et al., 1994). None of the drugs used in our experiments interfered with the NE assay. [Pg.402]


See other pages where Drug assay, electrochemical analysis is mentioned: [Pg.783]    [Pg.622]    [Pg.38]    [Pg.287]    [Pg.241]    [Pg.360]    [Pg.55]    [Pg.340]    [Pg.277]    [Pg.150]    [Pg.86]    [Pg.69]    [Pg.457]    [Pg.98]    [Pg.918]    [Pg.120]    [Pg.39]    [Pg.347]   
See also in sourсe #XX -- [ Pg.297 ]




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