Doxylamine

Alkylation of these as their sodium salts with the ubiquitous N-C2-chloroethyl)dimethylamine affords the desired antihistamines. There are thus obtained, respectively, mephenhydramine (23a) chlorphenoxamine (23b), and mebrophenhydramine (23c)Alkylation of the tertiary alcohol, 22b, with the pyrrolidine derivative, 24, affords meclastine (25). In much the same vein, reaction of 2-acetylpyridine with phenyImagnesium bromide gives the tertiary alcohol, 27. Alkylation in the usual way leads to the potent antihistamine, doxylamine (28). " ... 

C4H10CIN 107-99-3) see Bephenium hydroxynaphthoate Binedaline Brompheniramine Captodiame Carbinoxamine Chlorphenamine Chlorphenoxamine Cyclopentolate Dibenzepine Diltiazem Dimetindene Doxylamine Ethoheptazine Itopride hydrochloride Meclofenoxate Mepyramine Moxisylyte Normethadone Noxiptiline Pheniramine Phenyltoloxamine Tamoxifen Toremifene Trimethobenzamide Tripelennamine Zotepine... 

In this chapter, the voltammetric study of local anesthetics (procaine and related compounds) [14—16], antihistamines (doxylamine and related compounds) [17,22], and uncouplers (2,4-dinitrophenol and related compounds) [18] at nitrobenzene (NB]Uwater (W) and 1,2-dichloroethane (DCE)-water (W) interfaces is discussed. Potential step voltammetry (chronoamperometry) or normal pulse voltammetry (NPV) and potential sweep voltammetry or cyclic voltammetry (CV) have been employed. Theoretical equations of the half-wave potential vs. pH diagram are derived and applied to interpret the midpoint potential or half-wave potential vs. pH plots to evaluate physicochemical properties, including the partition coefficients and dissociation constants of the drugs. Voltammetric study of the kinetics of protonation of base (procaine) in aqueous solution is also discussed. Finally, application to structure-activity relationship and mode of action study will be discussed briefly. 

Procaine, doxylamine, and their related compounds are organic dibases and hence can be present in the forms of neutral molecule (B), protonated, univalent (BH+), and divalent cations (BH ) in both W and O phases. We consider the partition or transfer of a dibase between O and W phases in the forms of either B, BH tively, by... 

FIG. 5 The midpoint potential, E, of doxylamine at 0.1 M THexATClPB (NB)-O.IM LiCl, lOmM buffer (W) interface plotted against pH. 

Nonpharmacologic therapy such as dietary, physical, and behavioral approaches should be considered first. Pyridoxine (vitamin B6) 10 to 25 mg three to four times daily alone or in combination with an antihistamine such as doxylamine is often used for NVP.9,11,12 This combination was previously marketed as Bendectin or Debendox but was withdrawn due to concerns over possible teratogenic effects, although the literature did not support this claim.11,12 Pyridoxine is well tolerated, but doxylamine and other antihistamines commonly cause drowsiness. For more severe NVP, promethazine, meto-clopramide, and trimethobenzamide may be effective and have not been associated with teratogenic effects.9... 

AD Ayer, F Theeuwes, PS Wong. Pulsed drug delivery of doxylamine. US Patent 4,842,867, 1989. 

Korfmacher WA, Holder CL, Betowski LD, et al. 1987. Identification of two glucuronide metabolites of doxylamine via thermospray/mass spectrometry and thermospray/mass spectrometry/mass spectrometry. 

Antihistamines are popular as nonprescription (over-the-counter) sleep remedies (e.g., diphenhydramine, doxylamine, p. 114), in which case their sedative side effect is used as the principal effect. 

Doxylamine Dojq cycline Entromone HCG (= chorionic gona-... 

Dopamine, 95 Doxepin, 404 Doxylamine, 44 Dramamine , 41 Dromostanolone proprionate,... 

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