Stavudine Doxorubicin

Drugs that may interact with stavudine include didanosine, doxorubicin, hydroxyurea, methadone, ribavirin, and zidovudine. 

Drugs that may affect zidovudine include acetaminophen, atovaquone, bone marrow suppressive/cytotoxic agents (eg, adriamycin, dapsone), clarithromycin, doxorubicin, fluconazole, ganciclovir, methadone, nelfinavir/ritonavir, phenytoin, probenecid, ribavirin, rifamycins, stavudine, trimethoprim, and valproic acid. 

In vitro evidence suggests that doxorubicin may inhibit the activation of stavudine. 

Nucleoside reverse transeriptase inhibitors such as stavudine need to be phosphorylated within eells before they become effeetive. In vitro studies using mononueleated blood cells found that doxorubicin may interfere with stavudine phosphorylation at clinically relevant concentrations. The... 

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