Doxorubicin endometrial cancer

Although the endometrial cancers associated with tamoxifen are usually pure adenocarcinomas, other types of rare tumors have also been reported. A pure uterine rhabdomyosarcoma has been reported (99), and a mesodermal mixed tumor of the endometrium occurred 5 years after 5 years of tamoxifen therapy (100). The tumor responded only to combined treatment with doxorubicin, cyclophosphamide, 5-fluorouracil, and carbopla-tin. It is possible that this type of tumor arises later than adenocarcinomas and should be looked for during longterm use of tamoxifen. 

Doxorubicin (Adriamycin, Adria, Doxo, hydroxydaunorubicin) -Liposomal doxorubicin (Doxil) Breast cancer osteosarcoma and soft tissue sarcomas NHL HD ALL ANLL bladder cancer ovarian cancer thyroid cancer Wilms tumor neuroblastoma SCLC KS (liposomal) gastric cancer multiple myeloma NSCLC endometrial cancer... 

Julius JM, Tanyi JL, Nogueras-Gonzalez GM, Watkins JL, Coleman RL, Wolf JK, et al. Evaluation of pegylated liposomal doxorubicin dose on the adverse drug event profile and outcomes in treatment of recurrent endometrial cancer. Int J Gynecol Cancer 2013 23(2) 348-54. 

Doxorubicin Intercalator, forms free radicals, inhibits topoisomerase Hodgkin, breast, endometrial, lung, and ovarian cancers BMS—delayed CHF (dexrazoxane is an iron-chelating agent preventing the formation of free radicals it is not a free radical trapper ), alopecia, vesicant, radiation recall ... 

Clinical use Doxorubicin is a component of the ABVD regimen used in Hodgkin s disease and is used in treatment of myelomas, sarcomas, and breast, endometrial, lung, ovarian, and thyroid cancers. The main use of daunorubicin is in the treatment of acute leukemias. Idarubicin, a new anfhracycline, is approved for use in acute myelogenous leukemia. 

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