Dosage form body weight

In order to determine the optimal number of compartments, literature information on small intestinal transit times was utilized. A total of over 400 human small intestinal transit time data were collected and compiled from various publications, since the small intestinal transit time is independent of dosage form, gender, age, body weight, and the presence of food [70]. Descriptive statistics showed that the mean small intestinal transit time was 199 min with a standard deviation of 78 min and a 95% confidence interval of 7 min. The data set was then analyzed by arranging the data into 14 classes, each with a width of 40 min. Figure 9 shows the distribution of this data set. 

The usual adult dosage of the micronized ("microsize") form of the drug is 500 mg daily in single or divided doses with meals occasionally, 1 g/d is indicated in the treatment of recalcitrant infections. The pediatric dosage is 10 mg/kg of body weight daily in single or divided doses with meals. An oral suspension is available for use in children. 

Desmopressin (DDAVP) (see p. 712) 0.3-0.4 micrograms/kg body weight i.v. (also available in a concentrated intranasal form) increases factor VIII and von Willebrand factor levels by 3-5 times baseline in mild to moderate haemophilia A its use may render transfusion unnecessary after minor procedures such as dental extraction. It is cdso effective in mild to moderate t5q)e 1 von Willebrand s disease for which DDAVP offers nontransfusional treatment. Tachyphylaxis occurs with repeated dosage but stores are repleted after an interval of 2-4 days. Patients with severe deficiency of either factor and patients with any form of haemophilia B do not respond to DDAVP. Adverse effects include flushing, headache, tachycardia, mild h)q)ertension and hyponatraemia. 

Suppositories are solid dosage forms intended for insertion in body cavities like rectum, vagina, and occasionally in the urethra for local or systemic effects. The length, shape, and weight of these depend on the body cavity it is used for. These melt, soften, or dissolve after application depending on the type of suppository base applied. Cocoa butter base suppositories usually melt in contact with the body temperature. Other bases, such as polyethylene glycol, glycerin. 

Exposure to this compound therapeutically is by the oral route. Since variation in the AUG for oral busulfan results in substantial risk of over- or undertreatment with risk of toxicity or relapse, the use of an intravenous (IV) formulation has been studied. IV formulation reduces this variability by eliminating variability in absorption. Busulfan is a small, highly lipophilic molecule that easily passes the blood-brain barrier. The typical dosage level (tablet form) is 4-8 mg daily. The recommended intravenous dose given prior to bone marrow transplant is 0.8mgkg body weight given as a 2 h infusion every 6 h for 4 days. 

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