Dopamine short term control

As with many neurons (e.g. NA) there are presynaptic autoreceptors on the terminals of dopamine neurons whose activation attenuate DA release. Although most of these receptors appear to be of the D2 type, as found postsynaptically, D3 receptors are also found. It is possible that in addition to the short-term control of transmitter release they may also be linked directly to the control of the synthesising enzyme tyrosine hydroxylase. It seems that autoreceptors are more common on the terminals of nerves in the nigrostriatal (and possibly mesolimbic) than mesocortical pathway. 

Haloperidol is a phenylbutylpiperadine derivative antipsychotic, apparently cansed by dopamine-receptor blockage in CNS. It is indicated in the management of psychotic disorders control of Tonrette s disorder in children and adults management of severe behavioral problems in children short-term treatment of hyperactive children and long-term antipsychotic therapy (haloperidol decanoate). 

Olanzapine is an antipsychotic that controls psychotic symptoms throngh antagonism of selected dopamine and serotonin receptors in the central nervons system (CNS). It is indicated in the treatment of schizophrenia (oral) shortterm treatment of acnte mixed or manic episodes with bipolar I disorder (oral) in combination with lithium or valproate, for short-term treatment of acnte episodes associated with bipolar 1 disorder (oral) and treatment of agitation associated with schizophrenia and bipolar I mania (IM). 

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