Restless legs syndrome dopamine

FIGURE 38-1. Primary assessment and initial treatment for complaint of excessive daytime sleepiness. RLS, restless-legs syndrome NPSG, nocturnal polysomnography OSA, obstructive sleep apnea DA, dopamine agonist MSLT, multiple sleep latency test BZDRA, benzodiazepine receptor agonist SNRI, serotonin and norepinephrine reuptake inhibitor TCA, tricyclic antidepressant CPAP, continuous positive airway pressure. 

Clemens S., Rye D., Hochman S. (2006). Restless legs syndrome revisiting the dopamine hypothesis from the spinal cord perspective. Neurology 67, 125-30. 

Methadone 16 mg/day was effective in 29 patients with restless legs syndrome that had not responded to dopamine receptor agonists (9). Most (n = 17) were still taking methadone at follow-up and reported a 75% reduction in symptoms. Of 27 patients, 17 reported at least one adverse event while taking methadone, including constipation (n = 11), fatigue (n = 2), and insomnia, sedation, rash, reduced libido, confusion, and hypertension (one each). Five patients stopped treatment because of adverse events. 

Ropinirole is used for the treatment of Parkinson s disease and restless legs syndrome (RLS) (see footnote 1). It acts as a dopamine D2, D3, and D4 receptor... 

Nervous system There have been two reports of movement disorders induced by mirtazapine. Most of a case series of 14 patients with restless legs syndrome presented within a few days of starting treatment, and the symptom occurred more often in those who also took tramadol or dopamine receptor antagonists, such as antiemetics [72 ]. In one case, severe akathisia developed within 4 hours of a first... 

Yes, having excess dopamine in the brain doesn t simply make you even happier In fact, overstimulation causes the brain to malfunction, leading to conditions such as schizophrenia, attention deficit hyperactivity disorder (ADHD) and restless leg syndrome. 

A case of restless legs syndrome occurring in a 34-year-old female within 1 week of starting clozapine that responded to the addition of aripiprazole (partial dopamine agonist) is reported [111 ]. 

Discontinuation of dopamine agonist therapy may cause dopamine agonist withdrawal syndrome, a severe, stereotyped cluster of physical and psychological symptoms that temporally correlate with dopamine agonist withdrawal and are refractory to levodopa and other neuropsychiatric medications. The withdrawal syndrome has only been reported in Parkinson s disease. Thus, it has been xmclear whether the withdrawal syndrome is specific to Parkinson s disease. A case in a patient with restless legs syndrome is presented for the first time. 

Dorfman BJ, Nirenberg MJ. Dopamine agonist withdrawal syndrome in a patient with restless legs s)mdrome. Parkinsonism Relat Disord 2013 19(2) 269-70. 

---