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Dopamine/dopaminergic system drug dependence

Treatment for tobacco dependence involves a combination of behavioral therapies and pharmacological treatment. The most common pharmacological treatments involve nicotine repiacement therapy (NRT) and non-nicotine medications, including antidepressants. The antidepressant with the greatest weight of evidence for efficacy in the treatment of tobacco dependence is bupropion. The efficacy of bupropion for the treatment of tobacco dependence is attributed to the blockade of dopamine reuptake in the mesolimbic dopaminergic system. This area of the brain is believed to mediate reward for nicotine use and for other drug dependences. [Pg.259]

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