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Dopamine antipsychotic drugs

Grace AA, Bunney BS, Moore H, Todd CL (1997) Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. TINS 20 31-37... [Pg.184]

Antipsychotic Drugs Dopamine System Synaptic Transmission... [Pg.828]

Yokoi, F. et al. (2002). Dopamine D2 and D3 receptor occupancy in normal humans treated with the antipsychotic drug aripiprazole (OPC 14597) a study using positron emission tomography and (llC)raclopride. Neuropsychopharmacology, 27, 248-59. [Pg.61]

Clozapine is the prototype of atypical antipsychotic drugs, and it has been used effectively to treat patients with schizophrenia who are unresponsive or intolerant to typical antipsychotics [7]. Clozapine is characterized as atypical by its preferential binding to serotonin (5-HT2) and dopamine D4 receptors (D4) relative to dopamine D2 receptors [8]. A recent body of work also suggests that atypicality may be defined by the rate at which clozapine dissociates from D2 receptors. Specifically, clo-... [Pg.371]

Seeman P, Lee T, Chau-Wong M, Wong K. Antipsychotic drug doses and neuro-leptic/dopamine receptors. Nature 1976 261 717-719. [Pg.376]

The answer is c. (Hardman, pp 414-4163) Unwanted pharmacologic side effects produced by phenothiazine antipsychotic drugs (e.g., perphenazine) include Parkinson-like syndrome, akathisia, dystonias, galactorrhea, amenorrhea, and infertility. These side effects are due to the ability of these agents to block dopamine receptors. The phenothiazines also block muscarinic and a-adrenergic receptors, which are responsible for other effects. [Pg.155]

The number of D, and D2 receptors can be modulated by antagonists 222 Dopamine D2-like receptors appear to mediate the actions of antipsychotic drugs 222... [Pg.211]

Changes in dopamine receptor density may be involved in the side effects of antipsychotic drugs. One of the... [Pg.222]

Strange, P. G. Antipsychotic drugs importance of dopamine receptors for mechanisms of therapeutic actions and side effects. Pharmacol. Rev. 53 119-133, 2001. [Pg.224]

FIGURE 58-7 The IC50 values (ordinate) are the concentrations of the antipsychotic drugs that reduce the stereospecific component of 3H-haloperidol binding by 50%. The abscissa indicates the average values (and ranges) of doses used for schizophrenia. (From Seeman, P. et al. Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 261 717-719,1976)... [Pg.947]

Farde, L., Wiesel, F. A., Halldin, C. and Sedvall, G. Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch. Gen. Psychiatr. 45 71-76,1988. [Pg.960]

The predominant mechanism by which currently available antipsychotic medications interfere with dopamine activity is by blockade of dopamine receptors on neurons innervated by dopamine nerve terminals. Of the five types of dopamine receptors, all antipsychotics share in common the fact that they block the dopamine type 2 receptor, also known as the D2 receptor, to a varying degree. Some of the atypical antipsychotics also block other dopamine receptors (see Table 13.5). The role of blockade of Dl, D3, D4, and other dopamine receptors in the therapentic effects of antipsychotic drugs remains unclear. Aripiprazole is an exception to this in that it is a partial agonist at the D2 receptor. [Pg.365]


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See also in sourсe #XX -- [ Pg.37 ]




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Antipsychotic drugs

Antipsychotic drugs antipsychotics

Antipsychotic drugs dopamine hypothesis

Antipsychotic drugs dopamine receptor blockade

Antipsychotic drugs dopamine-blocking agents

Antipsychotic drugs serotonin-dopamine antagonists

Atypical antipsychotic drugs dopamine receptor affinities

Dopamine antagonists/antipsychotic drugs

Dopamine antipsychotic drug actions

Dopamine antipsychotic drug discovery

Dopamine antipsychotic drugs affecting

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