Donepezil Anticholinergics

Drugs that may affect donepezil are CYP450 3A4 and 2D6 inhibitors (eg, ketoconazole, quinidine) and CYP450 3A4 and 2D6 inducers (eg, carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampin). Drugs that may be affected by donepezil include anticholinergics, cholinometics/cholinesterase inhibitors, NSAIDs. 

This pharmacodynamic interaction suggests that donepezil should be avoided in patients with Alzheimer s disease who are taking anticholinergic drugs. 

Donepezil 2. Galant-amine 3. Memantine May be t anticholinergic effects Sage possesses some anticholinergic effects, such as that on sweating Be aware... 

Inhibitors of CYP450 2D6 and CYP450 3A4 may inhibit donepezil metabolism and increase its plasma levels Inducers of CYP450 2D6 and CYP450 3A4 may increase clearance of donepezil and decrease its plasma levels Donepezil may interact with anticholinergic agents and the combination may decrease the efficacy of both... 

---