Domino Nucleophilic Addition-Tsuji-Trost Reaction

Domino Nucleophilic Addition-Tsuji-Trost Reaction [Pg.301]

The palladium-catalyzed allylic substitution reaction presents one of the most versatile and efficient methods for C-C and C-X bond formation, and consequently a broad range of procedures have been reported [8]. However, despite this importance, the implementation of such Tsuji-Trost type reactions in sequential processes do not appear to have been fully exploited, even though it has obvious potential in enabling a rapid increase of structural complexity from simple starting materials by combining several synthetic transformations in a one-pot manner. [Pg.301]

Concise Synthesis of Tetrahydropyrans by a Tandem oxa-Michael-Tsuji-Trost Reaction [Pg.301]

Substituted tetrahydropyrans (THPs) present prevalent constitutional chemo-types and underlying structural motifs in numerous natural products, registered [Pg.301]

Concise Synthesis of Acetal-Protected 1,3-syn-Diols by a Tandem [Pg.304]

Domino Nucleophilic Addition-Tsuji-Trost Reaction 301... [Pg.301]

The oxa-Michael reaction is particularly suitable for the rapid generation of molecular complexity when it is embedded in domino reactions. The enolates generated by addition of alcoholates to conjugate acceptors are potent nucleophiles that can further react with suitable electrophiles. Wang and Menche used this reactivity to combine an oxa-Michael reaction with a Tsuji-Trost coupling (Scheme 5-211). " ... [Pg.962]

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