Dolabella auricularia, aurilol

The bromotriterpene aurilol (19) also was isolated from the sea hare Dolabella auricularia. Aurilol exhibits cytotoxicity against HeLa S3 cells with an IC50 of 4.3 pg/ml [36]. 

The sea hare Dolabella auricularia has furnished aurilol (628), which is cytotoxic (728) and for which the structure has now been fully assigned by total synthesis (729). The Indian Ocean red alga Chondria armata, a member of the Laurencia family, contains armatols A-F (629-634) (730). 

Suenaga K, Shibata T, Takada N, Kigoshi H, Yamada K (1998) Aurilol, a Cytotoxic Bromotriterpene Isolated from the Sea Hare Dolabella auricularia. J Nat Prod 61 515... 

The seven-member bromocyclic ether core of the marine natural products, (-l-)-enshuol 21 and (-l-)-aurilol 23, were furnished by treating 20 with A/-bromosuccinimide (NBS Scheme 42.8). (-l-)-aurilol 23 which was isolated from the sea hare, Dolabella auricularia, has displayed significant cytotoxicity against HeLa S3 cells. " ... 

Suenaga, K Shibata, T, Takada, N., Kigoshi, H and Yamada, K. (1998) Aurilol, a cytotoxic bromotriterpene isolated from the sea hare Dolabella auricularia.]. Nat. Prod., 61, 515-518. 

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