Docking status

Sousa, S. F., Fernandes, P. A., Ramos, M. J. (2006) Protein-ligand docking current status and future challenges. Proteins 65, 15-26. 

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A summary of the current status of protein-protein docking is that when this strategy has been applied to around ten test systems, one can generate a close model (2.5 A rmsd for the Ca atoms) to the true complex at a rank of ten or less for many of the systems studied. 

How useful is predictive protein docking in current work in structural bioinformatics In general, the status of the better algorithms is that for systems that do not involve substantial conformational change, one can generate a solution dose to the native structure (<3.0A rmsd for superposed interface Cot atoms) and this solution can be ranked at 10 or better. However results are this type are not guaranteed - typically it will occur for only half the systems studied. 

I need a docking bay which can handle casualties," he datavised back. "And put a pediatric team on alert status, as well as some biophysics specialists. These kids have had a real hard time on Lalonde, and that only finished when they got nuked."... 

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure, Vol.l9, No.8, pp. 1108-26 Kuhn, D., Weskamp, N., Hullermeier, E. Klebe, G. (2007). Functional classification of protein kinase binding sites using Cavbase. ChemMedChem, Vol.2, No. 10, pp. 1432-47... 

R. Mendez, R. Leplae, L. De Maria, and S. J. Wodak, Proteins, 52, 51-67 (2003). Assessment of Blind Predictions of Protein-Protein Interactions Current Status of Docking Methods. 

Sousa, S.F., Fernandes, P.A., and Ramos, M.J. 2006. Protein-Ligand docking Current status and future challenges. Proteins Structure Function Bioinformatics, 65,15-26. 

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