DNA templated self-assembly

Yan H, Park SH, Finkelstein G, Reif JH, LaBean TH (2003).DNA-templated self-assembly of protein arrays and highly conductive nanowires. Science 301 1882-1884. 

Figure 1.8 Two approaches of DNA-templated self-assembly (a) self-assembled DNA strands A (blue cross shape) carrying nanoparticle B pair with another self-assembled DNA strands A to form a 2-D nanogrid with nanoparticles (adapted from [38] with permission) (b) Complimentary DNA strands pair into nanogrids and functional materials incorporate with the nanogrid later (bl), forming arrays of nanomaterials (b2) (adapted from [37] with permission).

Sharma J, Chhabra R, Liu Y, Ke Y, Yan H. DNA-templated self-assembly of two-dimensional and periodical gold nanoparticle arrays. Angew Chem Int Ed 2006 45 730-5. 

Wei G, Wang L, Liu Z, Song Y, Sun L, Yang T, Li Z (2005) DNA-network-templated self-assembly of silver nanoparticles and their application in surface-enhanced raman scattering. J Phys Chem B 109 23941-23947... 

A last notable example is represented by a templated self-assembly of metallic nanoparticles by using DNA as a scaffold. This leads to the formation of extended, close-packed, ligand-stabilized metal nanoparticle structures, including long chains of nanoparticles [158]. 

DaDogrids. The assembly of periodic protein is achieved by the template self-assembly by using streptavidin on to the DNA nanogrids. The small square nanoribbons can also act as scaffolds for the synthesis of silver nanowires having uniform width and high conductivity (Becerril and Woolley, 2009 Cui et al., 2008 Dujardin et al., 2001 Reif et al., 2001 Sharma et al., 2008 Sun and Kiang, 2005 Young et al., 2014). 

Liu, D., Park, S.H., Reif, J.H., Labean, T.H., 2004. DNA nanotubes self-assembled from triple-crossover tiles as templates for conductive nanowires. Ptoc. Natl. Acad. Sd. USA 101, 717-722. 

Intact CCMV or its coat proteins have also been employed as viral building blocks for the self-assembly of molecular materials by Nolte, Comelissen and coworkers. For example, the coat proteins of CCMV were utilized to form DNA-templated tubular assemblies of viral coat proteins. As illustrated in Figure 11, the templates consisted of a single-strand DNA (ssDNA) of repeating thymine units of various lengths (T, where q is the number of thymine bases present). To form the negatively... 

Fig. 6 DNA- -PPO self-assembles into micelles, which are used as templates for carrying oiganic reactions (a) on the surface hy equipping the reactants at the 5 -taid of the cDNA or (h) in the core hy equipping the reactants at the 3 -end of the cDNA [80] (figure adapted with permission of...

Albeit the substantial progress in the bioelectrochemical activation of enzymes, one could identify two important future challenges in the field (i) The active relay units wiring the redox centers of the enzymes with the electrodes could be generated by photoinduced electron transfer. This could pave the way to the photochemical wiring of enzymes and to the development of photobiofuel cells, (ii) DNA scaffolds provide unique templates for the ordered self-assembly of molecular or biomolecular units through dictated hybridization. The ordering of relay units and enzymes, or of relay units photosystems, on DNA templates associated with electrodes may yield attractive new supramolecular nanostructures for bioelectronics and optobioelec tronic s. 

The self-assembling double-helical structure of DNA has provided the inspiration for a further area of supramolecular self-assembly, namely the use of metal ions to template the assembly of organic threads into... 

The scope of synthetic higher knots is relatively limited at present because of the tremendous synthetic challenges involved. However, we have already seen that natural system forms knots readily and DNA is a particular good candidate as a knot template because of its double helical nature. The knot-forming tendencies of DNA have been exploited particularly by the group of Nadrian C. Seeman (New York, USA) to produce by design using both self-assembly and deliberate manipulation (e.g. by... 

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