DNA/RNA bases

This technique provides an easy and convenient method to evaluate the association of small molecules to various polymorphic forms of nucleic acid structures from the measurement of absorbance changes in the absorption maximum of the hgand, where the nucleic acid has no absorbance. Information about overall DNA/RNA base preference and nature of binding can also... 

P. Mignon, S. Loverix, J. Steyaert, P. Geerlings, Influence of the ti-ti interaction on the hydrogen bonding capacity of stacked DNA/RNA bases. Nucleic Adds Res. 33, 1779-1789 (2005)... 

Assuming that each chain library contains some 10s variants, the total number of combinations exceeds 1016 a figure which can only be achieved in the PCR amplified DNA/RNA-based combinatorial libraries [163-165],... 

Table 16-1. Computed spectroscopic properties for the low-lying singlet excited states of DNA/RNA base monomers at the CASPT2//CASSCF level of calculation3...

Figure 16-2. Optimized structures for the ethene-like (gs/tnr )CI conical intersections for the five natural DNA/RNA base monomers...

Muniz-Miranda M, Gellini C, Salvi PR, Pagliai M (2010) Surface-enhanced Raman microspectroscopy of DNA/RNA bases adsorbed on pyroxene rocks as a test of in situ search for life traces on Mars. J Raman Spectrosc 41 12-15... 

Amongst the most widely used purine derivatives are 8-oxo-dG and 2-aminopurine (2AP). As the persistence of damaged DNA/RNA bases could lead to transcriptional/translational errors, organisms have evolved mechanisms to recognise such lesions. E. coli possesses proteins that specifically bind to RNA carrying 8-oxoguanosine. The effect of introducing 8-oxo-dG into telomeric... 

It remains an open question how the microorganisms in subsurface sediments are able to survive on the extremely low energy and carbon flux available for each cell. By DNA/RNA based techniques it could be shown that a significant fraction of the bacteria are alive and active rather than dormant or even dead (Schippers et al. 2005). Yet, calculations from cell numbers and measured or modeled mineralization rates show that the organic carbon flux available in million year old sediments allows only generation times of years to thousands of years (Whitman et al. 1998 Schippers et al. 2005). 

We have shown in the last topic that a triplet code with four letters (DNA/RNA bases) to choose from is mathematically sufficient to encode 20 amino acids, but is it structurally sufficient What is there about a set of three nucleotide bases that enables it to recognise and specify the very different chemical structure of a single amino acid Likewise, how can very similar codons specify very different amino acids. How is it that AUG can specify methionine while, with only one base different in each case, AAG specifies lysine, GUG specifies valine, AUC specifies isoleucine The answer to this puzzle lies, as so often, in the properties of a remarkable set of enzyme proteins and a matching set of RNA molecules called transfer RNA (tRNA), which together provide, in effect, an adaptor kit. 

Triplet code A description of the genetic code emphasising that it takes three DNA/RNA bases to specify one amino acid in a protein sequence. 

Serrano-Andres L, Merchan M Are the five natural DNA/RNA base monomers a good choice from natural selection A photochemical perspective. Journal of Photochemistry and Photobiology C-Photochemistry Reviews 2009, 10(1) 21— 32. 

QSPR Study of the Singlet Excitation Energy, Oscillator Strength, and Molar Absorption Coefficient of Five DNA-RNA Bases... 

In a recent work, hve physicochemical properties of DNA-RNA bases were thoroughly analyzed the first (AFl) and second (AF2) singlet excitation en-... 

Abbreviations str stretching, def deformation vibration. Sym symmetric, asym asymmetric, bk vibration of the DNA backbone U, C, T, A, G are ring breathing modes of the DNA/RNA bases. P protein, Tyr Tyrosine, Trp Tryptophan, Phe Phenylalanine. Assignments based on [1,19-23]. 

This section focuses on the distinction and identification of only a few and potentially even single biomolecules. The first part provides details about differentiation and identification of molecules such as amino acids and deoxyribonucleic acid/ribonucleic acid (DNA/RNA) bases by their TERS spectrum. In the second... 

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