DNA-mimetics

D. Formation of DNA Mimetics at the Air-Water interface Based on Hydrogen Bonding interaction... 

The triple helix is another type of superstructure of DNA [91]. A-T-T (A-T-U) and G-C-C base-trimers are formed by combination of Watson-Crick and Hoogsteen-type hydrogen bonding. Base-trimers are formed in the DNA-mimetic system at the air-water interface between the Watson-Crick-type monolayer and... 

Figure 2 DNA monomer design for elastin-mimetic repeat sequenee Lys-25 (the upper strand of the duplex represents the eoding sequence of the monomer in the 5 -3 direction).

The biological effects of IPG include tissue-specific regulation of lipolysis, lipogen-esis, glycolytic flux, protein synthesis and/or phosphorylation, DNA and RNA synthesis and also long-term actions such as cellular prohferation. IPG-P activates glycerol-3-phosphate acyl transferase [17], but almost aU the other insulin-mimetic activities reported were tested for IPG-A prepared in vitro by hydrolysis of highly purified GPI [1, 7, 8, 75, 76]. 

McKenzie, K. M., Videlock, E. I., Splittgerber, U., Austin, D. J. (2004). Simultaneous identification of multiple protein targets by using complementary-DNA phage display and a natural-product-mimetic probe. Angew. Chem. Int. Ed. Engl, 43, 4052-4055. 

Complexes that feature a-helices at interfaces were studied because a-helices constitute the largest class of protein secondary structure and mediate many protein interactions [30, 51]. Helices located within the protein core are vital for the overall stability of protein tertiary structure, whereas exposed a-helices on protein surfaces constitute central bioactive regions for the recognition of numerous proteins, DNAs, and RNAs. Importantly, helix mimetics have emerged as a highly effective class of PPI inhibitors [32, 36, 44, 52-55]. 

Complimenting the strand-break studies on DNA irradiated in the solid phase are studies that use high concentrations of radical scavengers to divide out the indirect from the direct effect in DNA irradiated in aqueous solution (see Refs. 15, 166, and 167). The work of Krisch et al. was one of the early studies that provided persuasive evidence that the direct effect is responsible for about half of the dsb produced under in vivo conditions. The absolute yields obtained from these cell mimetic conditions, however, are difficult to compare with the sohd-state results. 

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