DNA-ligand complexes

Ligands that interact physically with DNA have been extensively studied both by experimental techniques and by a variety of theoretical approaches. A diverse set of compounds have been studied, including compounds that intercalate between DNA sequences or bind in the minor groove.1 7 These studies have identified various factors that influence the stability of DNA ligand complexes in solution.6 8 9... 

Perales, J.C., Ferkol, T., Molas, M. and Elanson, R.W. (1994) An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes. Eur.J. Biochem., 226, 255-266. 

The application of Monte Carlo method for the study of hydration of nucleic acids, their components [77-80], and hydration of the DNA-ligand complexes (for example, dCpG with proflavine [81] and DNA with azinomycin B [82] intercalated complexes) was described in literature in detail. Monte Carlo simulations enable to evaluate the low energy conformations of various complexes of DNA fragments. 

By the fixation of a small molecule on the template, both replication and transcription are affected but with different relative efficiency, depending upon the structural characteristics of the DNA-ligand complex. 

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