DNA ligands

Melander, P. B. Dervan, and K. Luger. Blocking transcription through a nucleosome with synthetic DNA ligands. J. Mol. 

Riou JF et al. (2002) Cell senescence and telomere shortening induced by a new series of speciflc G-quadruplex DNA ligands. Proc Natl Acad Sci USA 99(5) 2672-2677... 

Escude C, Sun J-S (2005) DNA Major Groove Binders Triple Helix-Forming Oligonucleotides, Triple Helix-Specific DNA Ligands and Cleaving Agents. 253 109-148 Evans SV, see Schuman B (2007) 272 217-258 Van der Eycken E, see Appukkuttan P (2006) 266 1-47... 

Ligands that interact physically with DNA have been extensively studied both by experimental techniques and by a variety of theoretical approaches. A diverse set of compounds have been studied, including compounds that intercalate between DNA sequences or bind in the minor groove.1 7 These studies have identified various factors that influence the stability of DNA ligand complexes in solution.6 8 9... 

As expected, the performance of this filter over the whole 13C shift range surpasses that of a conventional single or even double filter. The authors have successfully applied this technique to a 2D NOESY spectrum with 13C-filtering in both dimensions, acquired on the 26 kDA complex between a [U-13C,15N]-labeled DNA-binding protein domain and a 15-mer DNA ligand (unlabeled) [24]. 

Shafer RH, Brown SC (1988) In Kallenbach NR (ed) Chemistry and physics of DNA-ligand interactions. Adenine Pre Schenectady, NY, p 109... 

Figure 3.3 Dynamic bis-salicylaldimine Ztf + complexafion identifies an oligo d(A T) DNA ligand. Right The selected A-methyl 2-aminoethyl pyrrolidine based bis-salicylaldimine complex 1 (hypothetical), which binds to oligo d(A T) DNA.

Figure 3.5 Disulfide-based dynamic combinatorial library selects for peptidic tiomodi-sulfide P-P and acridone-peptide heterodisulfide A-P G-quadruplex DNA ligands.

R. Mukhopadhyay, Aptamers Are Ready for the Spotlight, Anal. Chem. 2005, 77, 114A S. D. Mendonsa and M. T. Bowser, In Vitro Selection of High-Affinity DNA Ligands for Human IgE Using Capillary Electrophoresis, AnaL Chem. 2004, 76, 5387. 

Denison L, Haigh A, D Cunha G, Martin RF (1992) DNA ligands as radioprotectors Molecular studies with Hoechst 33342 and Hoechst 33258. Int J Radiat Biol 61 69-81 Deschavanne PJ, Debieu D, Chavaudra N, Malaise EP (1985) Radiosensitizing and cytotoxic properties of misonidazole on glutathione synthetase deficient human fibroblasts. Int J Radiat Biol 48 213-221... 

Lin, Y., Padmapriya, A., Morden, K.M. and Jayasena, S.D. (1995) Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition. Proc. Natl. Acad. Sci. USA, 92, 11044-11048. 

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