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DNA damage in Xenopus

Responses to DNA damage in Xenopus cell death or cell cycle arrest... [Pg.221]

Several cell-free assay systems have been used to dissect the mechanisms of DNA damage sensing in vitro. The most extensively applied system is the one using Xenopus extracts. As DNA replication can occur efficiently in Xenopus extracts, this system has been used to analyze how replication interference is sensed by checkpoint sensors (60, 61) and how activated checkpoint regulates DNA replication. The checkpoint can also be elicited in a replication-independent manner by various synthetic DNA structures in Xenopus extracts (9, 62). The checkpoint response in Xenopus extracts is often monitored by the phosphorylation of various checkpoint proteins. The association of checkpoint proteins with damaged chromatin or DNA is used to monitor the recognition of DNA damage in Xenopus extracts. [Pg.360]

See other pages where DNA damage in Xenopus is mentioned: [Pg.222]    [Pg.222]   
See also in sourсe #XX -- [ Pg.221 , Pg.222 , Pg.223 , Pg.224 , Pg.225 , Pg.226 , Pg.227 , Pg.228 , Pg.229 , Pg.230 , Pg.231 , Pg.232 , Pg.233 ]



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Damaged DNA

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