DNA cleaving agents

In the presence of Cu (II), the bithiazole (70) is a simple DNA cleaving agent, the first example of a 4,4 -bithiazole having this property <96CPB1761>. 

While enediyne natural products are efficient DNA cleaving agents, synthetic enediynes have been utilized widely to study the mechanistic details and obtain more efficient DNA cleavage activity. Simple enediynes (Fig. 8), with no binding units, show DNA cleavage albeit at very high concentra-... 

Keywords Nucleosome, Chromosome, Intercalators, Groove-binders, DNA-cleaving agents. 

Wender PA, Zercher CK, Beckham S, Haubold EM (1993) A photochemically triggered DNA-cleaving agent - synthesis, mechanistic and DNA cleavage studies on a new analog of the antitumor antibiotic dynemicin. J Org Chem 58 5867-5869... 

Toshima K, Takano R, Ozawa T, Matsumura S (2002) Molecular design and evaluation of quinoxa-line-carbohydrate hybrides as novel and efficient photo-induced GG-selective DNA cleaving agents. J Chem Soc Chem Commun 212-213... 

Rao (1991) showed that hematin catalyzed the autoxidation of hydroquinone or 1,2,4-benzenetriol in vitro, producing reduced oxygen species that may be responsible for protein or DNA binding after benzene exposure. Further work along this line of research has provided evidence that in vitro, chelates of iron and hydroquinone or 1,2,4-benzenetriol are potent DNA cleaving agents (Rao 1996 Singh et al. 1994), and that 1,2,4-benzenetriol, but not hydroquinone, causes the release of iron from ferritin (Ahmad et al. 1995). 

A keen recent interest in polyimine ruthenium(II) complexes (tris-bipyridinates, tris-phenanthrolinates, and their analogues) has largely been evoked by the ample scope they offer as selective DNA-cleaving agents and probes in biochemistry. Such ruthenium(II) complexes, as well as their photophysics, are of particular interest in creating the devices for molecular electronics (e.g., systems of the light-switch type) and in analytical detection of metal ions as well. 

Boger, D.L. Zhou, J. CDPL,-enediyne and CDPI3-EDTA conjugates a new class of DNA cleaving agents. J. Org. Chem. 1993, 58, 3018-3024. 

In order to function as an effective footprinting reagent, a metal complex must be a relatively nonspecific DNA cleaving agent. The presence of a... 

An alternative use was found for bis-propargylic sulfones by Nicolaou et al., who hypothesized that such systems may be DNA-cleaving agents through their ability to form... 

Scheme 7-40 Enediyne 171 as designed DNA-cleaving agent (Nicolaou et al.).

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