Dl dopamine receptor

Whereas inhibitors 1 and 2 and NIPP1 appear to be widely distributed in mammalian tissues, including brain, DARPP-32 shows a much more restricted distribution. The protein is enriched in discrete populations of neurons in the brain, most prominently those that express Dl-dopamine receptors (see Chs 12,46 and 54). Some neuronal cell types thus appear to contain unique species of phosphatase inhibitor proteins. The critical role played by these proteins in neuronal function is illustrated below. 

Koh PO, Bergson C, Undie AS, Goldman-Rakic PS, Lidow MS. 2003. Up-regulation of the Dl dopamine receptor-interacting protein, calcyon, in patients with schizophrenia. Arch Gen Psychiatry 60 311-319. 

Sawaguchi T, Goldman-Rakic PS. 1991. Dl dopamine receptors in prefrontal cortex Involvement in working memory. Science 251 947-950. 

Smiley JF, Levey AI, Ciliax BJ, Goldman-Rakic PS (1994) Dl dopamine receptor immunoreactivity in human and monkey cerebral cortex predominant and extrasynaptic localization in dendritic spines. Proc Natl Acad Sci USA 97 5720-5724. 

Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HHM, Cone R, Pribnow D, Salon J, Bunzow JR, Civelli O (1990) Cloning and expression of human and rat Dl dopamine receptors. Nature 347 76-80. 

Gerfen CR, Miyachi S, Paletzki R, Brown P (2002) Dl dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase. J Neurosci 22 5042-5054. 

Robertson HA, Peterson MR, Murphy K, Robertson GS (1989b) Dl-dopamine receptor agonists selectively activate striatal c-fos independent of rotational behaviour. Brain Res 503 346-349. 

Baufreton J, Garret M, Rivera A, de la Calle A, Gonon F, Dufy B, Bioulac B, Taupignon A (2003) D5 (not Dl) dopamine receptors potentiate burst-firing in neurons of the subthalamic nucleus by modulating an L-type calcium conductance. J Neurosci 23 816-825. 

Steiner H, Gerfen CR (1995) Dynorphin opioid inhibition of cocaine-induced, Dl dopamine receptor-mediated immediate-early gene expression in the striatum. J Comp Neurol 353 200-212. 

Criswell HE, Mueller RA, Breese GR (1989) Priming of Dl-dopamine receptor responses long-lasting behavioral supersensitivity to a Dl-dopamine agonist following repeated administration to neonatal 6-OHDA-lesioned rats. J Neurosci 9 125-133. 

Shippenberg TS, Bals-Kubik R, Huber A, Herz A (1991) Neuroanatomical substrates mediating the aversive effects of Dl dopamine receptor antagonists. Psychopharmacol 703 209-214. 

N-linked glycosylation is required for plasma membrane localization of D5, but not Dl, dopamine receptors in transfected mammalian cells. Mol Pharmacol 56 1071-1078... 

In the periphery, dopamine receptor levels are generally lower than those observed in brain, particularly in comparison to striatal dopamine receptor levels. Due to these low levels, knowledge of receptor distribution in the periphery is not yet comprehensive. Nevertheless, Dl-like receptors have been reported in the parathyroid gland and in the tubular cells of the kidney. D2-like dopamine receptors have also been observed in the kidney. In addition, dopamine D2 and D4 receptors have been found in the adrenal cortex, where they modulate aldosterone secretion. The... 

Dl-iike receptors activate the Gs transduction pathway, stimulating the production of adenylyl cyclase, which increases the formation of cyclic adenosine monophosphate (cAMP) and ultimately increases the activity of cAMP-dependent protein kinase (PKA). PKA activates DARPP-32 (dopamine and cyclic adenosine 3, 5 -monophosphate-regulated phosphoprotein, 32 kDa) via phosphorylation, permitting phospho-DARPP-32 to then inhibit protein phosphatase-1 (PP-1). The downstream effect of decreased PP-1 activity is an increase in the phosphorylation states of assorted downstream effector proteins regulating neurotransmitter... 

Govindaiah G., Cox C. (2005). Excitatory actions of dopamine via Dl-like receptors in the rat lateral geniculate nucleus. J. Neurophysiol. 94, 3708-18. 

Sanchez C.J., Bailie T.M., Wu W.R., Li N., Sorg B.A. Manipulation of dopamine dl-like receptor activation in the rat medial prefrontal cortex alters stress- and cocaine-induced reinstatement of conditioned place preference behavior. Neuroscience. 119 497, 2003. 

Anderson S.M., Bari A.A., Pierce R.C. Administration of the Dl-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats. Psychopharmacology (Berlin). 168 132, 2003. 

Self D., Barnhart W., Lehman D., Nestler E. Opposite modulation of cocaine-seeking behavior by Dl- and D2-like dopamine receptor agonists. Science. 271 1586, 1996. 

Castellano C, Cabib S, Palmisano A, Di Marzo V, Puglisi-Allegra S. (1997). The effects of anandamide on memory consolidation in mice involve both Dl and D2 dopamine receptors. Behav Pharmacol. 8(8) 707-12. 

The predominant mechanism by which currently available antipsychotic medications interfere with dopamine activity is by blockade of dopamine receptors on neurons innervated by dopamine nerve terminals. Of the five types of dopamine receptors, all antipsychotics share in common the fact that they block the dopamine type 2 receptor, also known as the D2 receptor, to a varying degree. Some of the atypical antipsychotics also block other dopamine receptors (see Table 13.5). The role of blockade of Dl, D3, D4, and other dopamine receptors in the therapentic effects of antipsychotic drugs remains unclear. Aripiprazole is an exception to this in that it is a partial agonist at the D2 receptor. 

Dyr, W., W. J. McBride, T. K. Lumeng, and J. M. Murphy. 1993. "Effects of Dl and D2 Dopamine Receptor Agents on Ethanol Consumption in the High-Alcohol-Drinking (HAD) Line of Rats." Alcohol 10 207-12. 

It has become evident, however, that there are several subcategories of dopamine receptors, and these receptor subtypes are identified as Dl, D2, D3,... 

Lidow MS, Elsworth JD, GoldmanRakic PS. 1997. Down-regulation of the Dl and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs. J Pharmacol Exp Ther 281 597-603. 

Hurd YL, Suzuki M, Sedvall GC (2001) Dl and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain. J Chem Neuroanat 22 127-137. 

Sutton MA, Beninger RJ (1999) Psychopharmacology of conditioned reward evidence for a rewarding signal at Dl-like dopamine receptors. Psychopharmacol 744 95-110. 

Friedman E, Jin LQ, Cai GP, Hollon TR, Drago J, Sibley DR, Wang HY (1997) Dl-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors evidence from D1A knockout mice. Mol Pharmacol 57 6-11. 

Svenningsson P, Lindskog M, Ledent C, Parmentier M, Greengard P, Fredholm BB, Fisone G (2000) Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine Dl, dopamine D2, and adenosine A2A receptors. Proc Natl Acad Sci USA 97 1856-1860. 

Undie AS, Weinstock J, Sarau HM, Friedman E (1994) Evidence for a distinct Dl-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain. J Neurochem 62 2045-2048. 

Dreher JK, Jackson DM (1989) Role of Dl and D2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of rats. Brain Res 487 261-211. 

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