Diverted total synthesis

A. Fiirstner, D. Kirk, M.D.B. Fenster, C. Aissa, D. De Souza and O. Mueller Diverted total synthesis preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties, Proc. Natl. Acad. Set, 2005, 102(23), 8103. 

Fuwa, H. et ah. Diverted total synthesis and biological evaluation of gambierol analogues Elucidation of crucial structural elements for potent toxicity, Chem. Eur. J., 10, 4894, 2004. 

DIVERSITY-ORIENTED SYNTHESIS, BIOLOGY-ORIENTED SYNTHESIS, AND DIVERTED TOTAL SYNTHESIS 533... 

Diversity-oriented synthesis Biology-oriented synthesis Diverted total synthesis... 

Fiirstner A. From total synthesis to diverted total synthesis case studies in the amphidinolide series. Isr. J. Chem. 2011 5L329-345. 

Mycolactone A/B (both E and Z isomers coexist in the purified microbial isolate) was difficult to obtain in pure form and therefore tiying to determine its mechanism of action and thus potential treatments was very diffieult. Soon after the publication by Altmann et al., a group in France reported a diverted total synthesis of mycolactone A/B and analogues, thus providing... 

One of the most general reaction sequences for the transformation of ketones into alkenes is reduction of the ketone to the corresponding alcohol followed by dehydration. While this method has been widely used, it often suffers from a lack of both stereo- and regio-chemical control in the formation of the double bond. Since the reduction of ketones and the subsequent dehydration of the resultant alcohols are covered in depth in other sections (this volume, Chapter 1.1 and Volume 6, Chapter 5.1), we present here only a few representative examples and divert the reader to these other sections for a detailed analysis of this area. In the total synthesis of (+)-occidentalol (Scheme 4), 1,2-reduction of the enone moiety gave... 

---