Antihypertensives Diuretics

Cyclothia2ide [2259-96-3] is another example of a duorine-free pharmaceutical (diuretic, antihypertensive) based on y -chloroduoroben2ene [625-98-9] where duorine activation is subsequentiy provided by two sulfonamide groups (156). 

Ketanserin (25) is an antihypertensive agent acting as an antagonist at both the serotonin-S2 and Qj-adrencrgic receptors [22]. Bendroflumethiazide (26) is the most notable in a class of diuretic-antihypertensive agents [5]... 

Therapeutic Function Diuretic antihypertensive Chemical Name 4-chloro-5-sulfamoyl-2, 6 -salicyloxylidide Common Name —... 

Different causes are seen for this condition, including low blood volume (due to, for example, dehydration, overuse of diuretics, anaemia or bleeding), relocation of the blood volume (varicose veins, postprandial symptoms), heart failure, long term immobilisation or drugs (diuretics, antihypertensives, antipsychotics). 

Reduction in blood pressure caused by treprostinil may be exacerbated by drugs that by themselves alter blood pressure, such as diuretics, antihypertensive agents, or vasodilators. Because treprostinil inhibits platelet aggregation, there is also a potential for increased risk of bleeding, particularly among patients maintained on anticoagulants. 

Mecfianism of Action A guanidine derivative that acts as a potassium-sparing diuretic, antihypertensive, and antihypokalemicby directly interfering with sodium reabsorption in the distai tubule, TherapeuticEffect Increases sodium and water excretion and decreases potassium excretion. 

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