Antihypertensives diuretic activity

Changing the substitution pattern on the carbo-cyclic ring of the benzothiadiazine diuretics is well known to have a marked effect on the qualitative biological activity. Thus, the direct analogue of the diuretic chlorothiazide (199) in which chlorine replaces one sulfonamide group, diazoxide (200), shows negligible diuretic activity instead the compound is a potent antihypertensive vasodilator. 

EtOH i pressor response W/ epi i effects W/ NSAIDs EMS Some formulations contain a preservative that can cause anaphylactic Rxns can cause lupus-like erythematosus (muscle pain, fever, rash) use other antihypertensives/diuretics w/ caution concurrent EtOH use T effects OD May cause profound hypotension, HA and tach give IV fluids activated charcoal may be effective... 

Also shown in Table I is diuretic and antihypertensive activity in a spontaneously hypertensive rat screen. Dopamine was not significantly active at 0.5 mg/kg i.p. presumably due to its short biological half-life. SK F 38393 is active both as a natriuretic and an antihypertensive agent. The diuretic activity has been characterized in other studies (26,27). It is natriuretic given i.p. or orally to saline-loaded, water-loaded, and... 

Hydrochlorothiazide/triamterene is a diuretic combination. Hydrochlorothiazide inhibits reabsorption of sodium and chloride in the ascending loop of Henle and early distal tubules. Triamterene interferes with sodium reabsorption at the distal tubule. The combination provides additive diuretic activity and antihypertensive effects and minimizes potassium depletion. They are indicated in the treatment of edema or hypertension in patients who have, or are at risk of developing, hypokalemia. 

Several 2,3-dihydrobenzofuran-5-sulfamido derivatives possess diuretic and antihypertensive properties. As an example, 6,7-dichloro-2,3-dihydrobenzofuran-2-ethylcarboxylate 92 reacted with chlorosulfonic acid to give the corresponding 5-sulfonyl chloride 93 which, after condensation with dimethylamine and hydrolysis, gave the dimethylsulfonamide derivative 94 which had diuretic activity (Equation 27). °... 

Cyclothia2ide [2259-96-3] is another example of a duorine-free pharmaceutical (diuretic, antihypertensive) based on y -chloroduoroben2ene [625-98-9] where duorine activation is subsequentiy provided by two sulfonamide groups (156). 

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