Dithioacetic acid

Other Radioprotective Chemicals. The bis-methylthio- and methylthioamino-derivatives of 1-methylquinolinium iodide and l-methylpyridinium-2-dithioacetic acid provide reasonable protection to mice at much lower doses than the aminothiols, which suggests a different mechanism of action (139). One of these compounds, the 2-(methylthio)-2-piperidino derivative of the l-methyl-2-vinyl quinolinium iodide (VQ), interacts with supercoUed plasmic DNA primarily by intercalation. Minor substitutions on the aromatic quinolinium ring system markedly influence this interaction. Like WR-1065, VQ is positively charged at physiological pH, and the DNA-binding affinities of VQ and WR-1065 appear to be similar. 

Acetvldiphenylsulfide is reacted with carbon disulfide in an initial step to give 4-phenyl-thiobenzoyl dithioacetic acid. That, in turn, is reacted with o-phenylenediamine. 

C17H21NO2S 1227-99-2) see Tiemonium iodide (phenylthio)acetaldehyde (CgHjOS 66303-55-7) see Sumatriptan (4-phenylthiobenzoyl)dithioacetic acid (C15H12OS3 41054-41-5) see Tibezonium iodide... 

Dithioacids themselves (R CSSH) could be prepared in about a 40-50% yield by addition of Grignard reagents to caibon disulfide in THF as the solvent, followed by acidification in the presence of ether or pentane [143], Hartke has reported that the yields of dithioacids could be improved by reverse addition of the Grignard reagent to carbon disulfide [144], a protocol previously used by Julia [145] in the preparation of dithioesters from allylic organometallics. A 70-80% yield of dithioacetic acid was thus achieved on a molar scale. 

Preparation of dithioacetic acid by addition of methylmagnesium iodide to carbon disulfide... 

P H3C-CM71 3 30 2 P H3C-C 195 2 Thioacetic acid 392 p H3C-C2341 Dithioacetic acid... 

Dithioacetic acid, phenyl-metal complexes, 646 Dithiobenzoic acid metal complexes, 646 colours, 646 Dithiobiuret metal complexes, 640 Dithiocarbamic acid metal complexes, 585 Ditbiocarbazic add metal complexes, 803 Dithiocarbimic acid metal complexes, 588 Dithiocarbimic acid, cyano-metal complexes, 808 Dithiocarboxylic acids... 

The reaction between AuCLi and dithioacetic acid gives the tetramer [Au(S2CMe)]4. The molecnlar stmctnre consists of a square of gold atoms with the dithioacetato ligands bridging above and below the A114 plane as shown in (7). 

Treatment of () -C7F[7)Ti( -C5H5) with dithioacetic acid, CF13CS2FI, leads to loss of the cycloheptatrienyl to give (jj -... 

A nickel(II) dimer, [Ni2(CH3CS2)4], precipitates immediately from a mixture of nickel chloride and dithioacetic acid (85, 86). The nickel(II) dimer is oxidized to the mixed-valence state, [Ni2(CH3CS2)4l], upon reacting with a half equivalent amount of iodine in CS2 solution (86). An attempt to obtain the Ni(III) dimer [Ni2(CH3CS2)4l2] was not successful. 

Dithioacetic acid derivatives add to 1,4-benzo- or 1,4-naphthoquinones to give, after oxidation of the adduct with silver oxide or chloranil, the quinones 217 and 218 (69LA103). Quinones 218 were prepared also from 2,3-dichloro-1,4-naphthoquinone and salts of dithiocarbamic acids (51JA3459) and those of type 219 by oxidation of the corresponding hydroquinones. From reduction potentials and the semiquinone formation constants, it was concluded that their anion radicals are thermodynamically stable (86CC1489). 

With the cydopentadienyl ligand, vanadium forms the simple sandwich compound, "vanadocene , [V( - -C5Hj)2] which is dark violet, paramagnetic (3 unpaired electrons) and extremely air-sensitive. Oxidative addition reactions are possible and provide compounds such as [V()9 -CjH5)2C1 ] (n = 1,2,3) and LV(rj -C5H5)2R2], while it.s reaction with dithioacetic acid produces the dark-brown tetramer [V4(fj -C H5)4( 3-S4), Fig. 22.11. " With four V " atoms, eight electrons are available for six V-V bonds and the implied bond order of 2/3... 

It has been reported that dithiocarboxylic acids exist as monomers in dilute solution and as hydrogen-bonded dimers in concentrated solution. NMR spectra for neat dithioacetic acid 6 revealed that reversible covalent associations exist, resulting in dimer 7 and cyclic trimer 8 [22]. At 19.5 °C,the ratios of these spices are 61% monomer, 38% 7 and 1% 8. 

Treatment of dithioacetic acid with 2 equiv of BuLi generates the dilithium dithioenolate 13, which reacts at the terminal carbon with the carbonyl carbon of enone 14. The resulting lithium dithioate is methylated with methyl iodide to provide the methyl p-hydroxy dithioate 15 (Scheme 3) [24]. 

The trimer 82 of dithioacetic acid has been observed in dilute CD2CI2 solution. The conformation of this species, however, was not determined <1990JA4697>. 

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