Dissolution of drugs

Hotter, D., Dressman, J. B. Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv. Drug Deliv. 

Fig. 11 Effect of particle size of phenacetin on dissolution of drug from granules containing starch and gelatin. Q, particle size 0.11-0.15mm A, particle size 0.15-0.21 mm , particle size 0.21-0.30mm , particle size 0.30-0.50mm , particle size 0.50-0.71 mm. (From Ref. 17.).

AD Koparkar, LL Augsburger, RF Shangraw. Intrinsic dissolution rates of tablet filler-binders and their influence on the dissolution of drugs from tablet formulation. Pharm Res 7 80-86, 1990. 

The dissolution of drugs has been described by the Noyes-Whitney equation as later modified by Nernst and Brunner [21, 22] ... 

The IV-IVC is generally established by comparing in vitro dissolution of drug with certain in vivo PK parameters. There are certain FDA guidelines for this purpose, where the correlations are categorized as Level A, Level B, Level C, and multiple Level C correlations.84... 

Liberation of drug from the dosage form. For example, the dissolution of drug from a tablet ... 

The effect of electrolytes and drugs on the cloud point of hydroxypropylmethylcellulose gels and the dissolution of drugs from hydroxypropylmethylcellulose matrix tablets... 

In Vivo Dissolution The process of dissolution of drug in the gastro-intestinal tract. 

In Vivo Release In vivo dissolution of drug from a dosage form as determined by deconvolution of data obtained from pharmacokinetic studies in humans (patients or healthy volunteers). 

Figure 26.12 Measuring setup for investigation of the dissolution of drugs from pharmaceutical preparations T, thermometer K, stirrer P, peristaltic pump E, silicone-rubber-based electrode E2, silver-silver chloride reference electrode. [From Ref. 169.]...

FIGURE 6.2 Dissolution of drug A lipid formulation in various dissolution media. 

Hater, D. and Dressman, J.B. In uence of physico chemical properties on dissolution of drugs in the gastrointestinal tracAdv. Drug Delivery Re 46 (2001), 75. 

Both treatments assume that the dissolution of drug is rapid compared with the diffusion of drug, and both predict release of drug that is linear with Vf. This is a consequence of the increased diffusional distance and decreased diffusional area at the diffusion front as drug release proceeds. Figure 4.1 illustrates the amount released Qt versus square-root-time -Jt plots for two cases both dispersed (loading greater than saturation,... 

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