Dissolution apparatus Small volume vessel

Reducing dissolution vessel volume is one of the simple approaches for equipment manufacturers to help overcome the problem of low dmg concentrations for low-dose products. Many apparatuses modified to small volume dissolution vessels are now commercially available. A list of manufacturers for these special apparatuses is provided below ... 

When dealing with small volumes, a fairly common approach has been to take the glass vessel and reduce its size to 100-200 mL, and to also scale down the size of the paddle shaft or basket shaft and baskets accordingly (Fig. 11.1). In most cases, the modified and smaller vessels are configured within the standard dissolution tester. Table 11.1 provides a comparison between standard USP dissolution Apparatus 2 and minidissolution assembly. Because the minidissolution assembly is not compendial, chemical and mechanical calibration procedures should be developed for performance verification. 

---