Dissociation reorganization dynamics

Carbonyl compounds are also suited to the investigation of the role of solvent reorganization in the dynamics of intramolecular dissociative electron transfer as observed in a series of phenacyl derivatives bearing various leaving groups.199... 

The reorganization or collapse of the switch segments on GTP hydrolysis (signal termination) may occur before phosphate is released from the Gz GDP Mg2+ Pi complex, and may be triggered by dissociation of Mg2+ from the catalytic site or formation of a hypothetical catalytic intermediate (e.g., metaphosphate). GTP hydrolysis and switch reorganization can be mechanistically decoupled as a consequence of a point mutation that alters the dynamics of Gz and perturbs the Mg2+-binding site in the catalytically activated state. 

We have shown how organolithium compounds adopt a variety of structures which differ in state of aggregation and degree of solvation. These species interconvert rapidly at equilibrium by different mechanisms, such as intermolecular C—Li exchange ligand transfer and dissociation-recombination processes as well as first-order reorganizations such as inversion and rotation. Dynamics of many of these processes have been determined by our methods of NMR line shape analysis. 

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