Disruption phenotypes

Recently, the notion that the chronicity of inflammation may not actually drive the fibrogenic process has been widely appreciated (Tables 1, 2, and 3). Some propose that it is indeed the alteration of the mesenchymal cell phenotypes that disrupts the balance between collagen synthesis and degradation in the wound-healing process, highlighted by clinical evidence that shows unsuccessful treatment of fibrosis with anti-inflammatory or immunosuppressive drugs (18,19). One scenario is that mesenchymal cells (myofibroblasts and fibroblasts) are phenotypically altered and thus do not undergo apoptosis after resolution. 

The ability to introduce the lux phenotype into different bacterial species provides a convenient method for rapidly screening in a simple and sensitive way the presence of specific bacteria and for monitoring their growth and distribution in the environment [198], Another application of transformed bacteria deals with specific susceptibility in toxicity tests the presence of agents that disrupt or kill the bacteria destroys the metabolism, thus eliminating light emission. Some examples are listed in Table 7. 

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