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Disintegrants alginic acid

Surface area and moisture uptake have been related to the disintegration properties of excipients such as crosspovidone, starch, and alginic acid [17]. The surface areas of the three materials were measured, and a linear correlation was found between the maximum moisture sorption and specific surface area for the three disintegrants. The greater the surface area of the material, the more numerous were the sites for capillary attraction of water to its surface. It was postulated that the capillary action appears to be responsible for the disintegration properties of the materials. [Pg.262]

Shotton et al. [38] Van Kamp et al. [39] Sulfadiazine (D) Povidone (B) No filler Prednisone (D) Maize starch Na calcium alginate Alginic acid Microcrystalline cellulose Colloidal aluminum silicate Extra > intra Extragranular incorporation yielded fastest disintegration, but intragranular incorporation yielded finer particles. Equal distribution of disintegrants is recommended. [Pg.287]

Disintegrating and wetting agents agar, alginic acid, bentonite, microcrystalline cellulose, gelatin, magnesium aluminium silicate, methylcellulose, sodium lauryl sulphate, starch, and starch derivatives. [Pg.50]

The method of incorporation of disintegrants in granulation has been controversial. Should the disintegrant be all extragranular, all intragranular, or divided between these two locations Shotton and Leonard reported that maize starch, sodium calcium alginate, alginic acid. [Pg.3562]

Alginic acid is used in a variety of oral and topical pharmaceutical formulations. In tablet and capsule formulations, alginic acid is used as both a binder and disintegrating agent at concentrations of 1-5% Alginic acid is widely... [Pg.21]

Satialgine H8. [Mendell] Alginic acid NF disintegrant for pharmaceutical tabletting. [Pg.326]

Alginic acid Calcium carboxymethyl cellulose Methacrylic acid-divinylbenzene copolymer Silica Soybean (Glycine soja) flour disintegrant, tablet pharmaceuticals Guar (Cyanopsis tetragonoloba) gum disintegrant, tablets... [Pg.5099]

Erodible inserts contain drug dispersed throughout a polymeric matrix (polylactic, polyglycolic, alginic acid, polypeptides, etc.) the drug is gradually leached from the matrix as it slowly erodes and disintegrates in the cul-de-sac. Devices of this kind have been... [Pg.188]

Alginic acid Extracted from various species of brown seaweed Binder, Disintegrant... [Pg.3]

See other pages where Disintegrants alginic acid is mentioned: [Pg.304]    [Pg.285]    [Pg.15]    [Pg.128]    [Pg.286]    [Pg.161]    [Pg.74]    [Pg.3]    [Pg.21]    [Pg.112]    [Pg.327]    [Pg.223]    [Pg.1011]    [Pg.20]    [Pg.33]    [Pg.19]    [Pg.22]    [Pg.35]    [Pg.1312]   
See also in sourсe #XX -- [ Pg.21 ]



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Alginates/alginic acid

Alginic acid

Disintegrants

Disintegrates

Disintegration

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